ArticleGenetics1998
Identification and mapping of two divergent, unlinked major histocompatibility complex class II B genes in Xiphophorus fishes.
Article in Genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 39 citations in OpenAlex.
- Comprehensive analysis of medaka major histocompatibility complex (MHC) class II genes: implications for evolution in teleosts.Immunogenetics · 2013Article
- Article
- Divergent patterns of selection on the DAB and DXB MHC class II loci in Xiphophorus fishes.Genetica · 2009Article
- Multiple expressed MHC class II loci in salmonids; details of one non-classical region in Atlantic salmon (Salmo salar).BMC genomics · 2008Article
- A theoretically estimated optimal cooling rate for the cryopreservation of sperm cells from a live-bearing fish, the green swordtail Xiphophorus helleri.Theriogenology · 2005Article
- Comparative genomics of major histocompatibility complexes.Immunogenetics · 2005Review
- Sperm cryopreservation of a live-bearing fish, the platyfish Xiphophorus couchianus.Theriogenology · 2004Article
- Alternative splicing of major histocompatibility complex class II DXB transcripts in Xiphophorus fishes.Immunogenetics · 2004Article
- A microsatellite genetic linkage map for Xiphophorus.Genetics · 2004Article
- Initial studies on sperm cryopreservation of a live-bearing fish, the green swordtail Xiphophorus helleri.Theriogenology · 2004Article
- Sperm cryopreservation of green swordtail Xiphophorus helleri, a fish with internal fertilization.Cryobiology · 2004Article
- Primitive synteny of vertebrate major histocompatibility complex class I and class II genes.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
We have isolated two major histocompatibility complex (MHC) class II B genes from the inbred fish strain Xiphophorus maculatus Jp 163 A. We mapped one of these genes, designated here as DXB, to linkage group III, linked to a malic enzyme locus, also syntenic with human and mouse MHC. Comparison of genomic and cDNA clones shows the gene consists of six exons and five introns. The encoded beta1 domain has three amino acids deleted and a cytoplasmic tail nine amino acids longer than in other teleost class II beta chains, more similar to HLA-DRB, clawed frog Xela-F3, and nurse shark Gici-B. Key residues for disulfide bonds, glycosylation, and interaction with alpha chains are conserved. These same features are also present in a swordtail (Xiphophorus helleri) genomic DXB PCR clone. A second type of class II B clone was amplified by PCR from X. maculatus and found to be orthologous to class II genes identified in other fishes. This DAB-like gene is 63% identical to the X. maculatus DXB sequence in the conserved beta2-encoding exon and was mapped to new unassigned linkage group LG U24. The DXB gene, then, represents an unlinked duplicated locus not previously identified in teleosts.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.