Evidence map›Paper›PMID 9691036›Full record

ArticleGenetics1998

Analysis of fluG mutations that affect light-dependent conidiation in Aspergillus nidulans.

L N Yager, H O Lee, D L Nagle, J E Zimmerman

Abstract read
In one paragraph

Article in Genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. The Early Asexual Development RegulatorFrontiers in microbiology · 2019
    Article
  2. Article
  3. Review
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  5. Article
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  7. Article
  8. Review
  9. Article
  10. Light effects on cell development and secondary metabolism in Monascus.Journal of industrial microbiology & biotechnology · 2005
    Article
  11. Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

L N YagerDepartment of Biology, Temple University, Philadelphia, Pennsylvania 19122, USA. lyager@thunder.ocis.temple.edu
H O Lee
D L Nagle
J E Zimmerman

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conidiation in Aspergillus nidulans is induced by exposure to red light but can also be induced by blue light in certain mutant strains. We have isolated a mutation in the fluG gene that abolishes responsiveness to red light but does not affect the response to blue light. It has been shown that the veA1 (velvet) mutation allows conidiation to occur in the absence of light. We have identified three other fluG mutations that suppress the veA1 phenotype; these double mutants do not conidiate in the dark. The mutations described here define two new phenotypic classes of fluG alleles that display abnormal responses to light. We have characterized these mutations with respect to their molecular identity and to their effect on fluG transcription. Although it has been shown that fluG is required for the synthesis of an extracellular factor that directs conidiation, we do not detect this factor under conditions that promote conidiation in the veA1 suppressors. Furthermore, extracellular rescue is not observed in fluG deletion strains containing the wild-type veA allele. We propose that a genetic interaction between fluG and veA influences the production of the extracellular signal and regulates the initiation of conidiation.

Indexed as

Genes, FungalMutationAllelesAmino Acid SequenceAspergillus nidulansBase SequenceDNA, FungalDNA PrimersFungal ProteinsLightPhenotypeSequence Homology, Amino AcidSequence Homology, Nucleic AcidSpores, FungalSuppression, GeneticDNA, FungalDNA PrimersFLUG protein, Emericella nidulansFungal Proteins

Identifiers

PMID9691036
PMCPMC1460255

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.