ArticleDigestive diseases and sciences1998
Analysis of signaling protein kinases in human colon or colorectal carcinomas.
Article in Digestive diseases and sciences, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 50 citations in OpenAlex.
- Claudin-6 is down-regulated in gastric cancer and its potential pathway.Cancer biomarkers : section A of Disease markers · 2020Article
- Evaluation of the use of therapeutic peptides for cancer treatment.Journal of biomedical science · 2017Review
- MAP kinase genes and colon and rectal cancer.Carcinogenesis · 2012Article
- Increased tumor necrosis factor receptor 1 expression in human colorectal adenomas.World journal of gastroenterology · 2012Article
- The serine protease inhibitor serpinE2 is a novel target of ERK signaling involved in human colorectal tumorigenesis.Molecular cancer · 2010Article
- p38 MAP kinase inhibition promotes primary tumour growth via VEGF independent mechanism.World journal of surgical oncology · 2009Article
- KRAS/BRAF mutation status and ERK1/2 activation as biomarkers for MEK1/2 inhibitor therapy in colorectal cancer.Molecular cancer therapeutics · 2009Article
- Gene expression profiling following constitutive activation of MEK1 and transformation of rat intestinal epithelial cells.Molecular cancer · 2006Article
- Cholecystokinin 1 receptor modulates the MEKK1-induced c-Jun trans-activation: structural requirements of the receptor.British journal of pharmacology · 2006Article
- Arachidonic acid and colorectal carcinogenesis.Molecular and cellular biochemistry · 2003Review
- Identification of expressed genes linked to malignancy of human colorectal carcinoma by parametric clustering of quantitative expression data.Genome biology · 2003Article
- Novel agents for the prevention of breast cancer: targeting transcription factors and signal transduction pathways.Journal of mammary gland biology and neoplasia · 2003Review
- Apoptosis and melanogenesis in human melanoma cells induced by anthrax lethal factor inactivation of mitogen-activated protein kinase kinase.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- NF-kappaB, p38 MAPK and JNK are highly expressed and active in the stroma of human colonic adenomatous polyps.Oncogene · 2001Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Extracellular signal-related kinase (ERK) and c-Jun N-terminal kinase (JNK) mitogen-activated protein (MAP) kinases are highly activated in an in vivo rat model of colorectal carcinogenesis. In addition, other protein kinases such as c-Src and c-Yes have been shown to be up-regulated in some human colon cancers. To evaluate the activity of these kinases in human colorectal carcinomas, we examined colon cancers and adjacent normal intestinal mucosa from 11 patients. Moderate increases in ERK and JNK activities, in addition to up-regulation of c-Src, p125FAK, and tyrosine-phosphorylated proteins, were observed in a subset of the colorectal carcinomas. There was a significant correlation found between levels of c-Src, p125FAK, and tyrosine-phosphorylated proteins, as well as between c-Src protein levels and JNK activity. This is the first report that examines several different kinases as markers to characterize colorectal cancers in the same carcinoma sample, allowing the determination of correlations between markers in the same tumors.
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