ArticleProceedings of the National Academy of Sciences of the United States of America1998
Detection of subtle phenotypes: the case of the cell adhesion molecule csA in Dictyostelium.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Many Cells Make Light Work: Self-Generated Gradients OrganizeCold Spring Harbor perspectives in biology · 2026Review
- Dictyostelium discoideum chemotaxis is altered by hypoxia to orient streaming toward higher oxygen levels.BMC molecular and cell biology · 2025Article
- The greenbeard gene tgrB1 regulates altruism and cheating in Dictyostelium discoideum.Nature communications · 2024Article
- Prestalk-like positioning of de-differentiated cells in the social amoeba Dictyostelium discoideum.Scientific reports · 2024Article
- Fat-containing cells are eliminated duringBiology open · 2017Article
- A set of genes conserved in sequence and expression traces back the establishment of multicellularity in social amoebae.BMC genomics · 2016Article
- Molecular mechanism of flocculation self-recognition in yeast and its role in mating and survival.mBio · 2015Article
- Differential adhesion between moving particles as a mechanism for the evolution of social groups.PLoS computational biology · 2014Article
- A new social gene in Dictyostelium discoideum, chtB.BMC evolutionary biology · 2013Article
- Rapid antagonistic coevolution between strains of the social amoeba Dictyostelium discoideum.Proceedings. Biological sciences · 2012Article
- Dictyostelium dynamin B modulates cytoskeletal structures and membranous organelles.Cellular and molecular life sciences : CMLS · 2011Article
- Evolution of cooperation and control of cheating in a social microbe.Proceedings of the National Academy of Sciences of the United States of America · 2011Review
- Deficiency of huntingtin has pleiotropic effects in the social amoeba Dictyostelium discoideum.PLoS genetics · 2011Article
- A cytohesin homolog in Dictyostelium amoebae.PloS one · 2010Article
- Polymorphic members of the lag gene family mediate kin discrimination in Dictyostelium.Current biology : CB · 2009Article
- Kin discrimination increases with genetic distance in a social amoeba.PLoS biology · 2008Article
- SrfB, a member of the Serum Response Factor family of transcription factors, regulates starvation response and early development in Dictyostelium.Developmental biology · 2008Article
- Mu- and kappa-opioids induce the differentiation of embryonic stem cells to neural progenitors.The Journal of biological chemistry · 2006Article
- SadA, a novel adhesion receptor in Dictyostelium.The Journal of cell biology · 2002Article
- Becoming Multicellular by Aggregation; The Morphogenesis of the Social Amoebae Dicyostelium discoideum.Journal of biological physics · 2002Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dictyostelium amoebae aggregate into a multicellular organism by cAMP-driven chemotaxis and cell-cell adhesion. Cell adhesion is mediated by an EDTA-sensitive and an EDTA-resistant adhesion system. The latter is developmentally regulated and triggered by homophilic interactions of the membrane glycoprotein csA; on disruption of the encoding gene, EDTA-resistant contacts fail to form. Nevertheless, csA-null cells under usual laboratory conditions aggregate normally and complete development. By using experimental conditions that reproduce more closely the habitat of Dictyostelium amoebae, evidence is provided that csA is required for development and that its expression confers a selective advantage to populations of wild-type cells over csA-null mutants. The latter display reduced cell-cell adhesion, increased adhesiveness to the substratum, and slower motility, which lead to their sorting out from aggregating wild-type cells. It is proposed that the experimental conditions commonly used in the laboratory are not stringent enough to assess the developmental role of csA and other proteins. The assay described can be used to detect subtle phenotypes, to reexamine the developmental role of apparently nonessential genes, and to test the validity of recent models on emergence and maintenance of apparent genetic redundancy.
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