ArticleProceedings of the National Academy of Sciences of the United States of America1998
A way of following individual cells in the migrating slugs of Dictyostelium discoideum.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Differential cell motion: A mathematical model of anterior posterior sorting.Biophysical journal · 2023Article
- Visualization of c-di-GMP in multicellularFrontiers in cell and developmental biology · 2023Article
- Calcium responses to external mechanical stimuli in the multicellular stage of Dictyostelium discoideum.Scientific reports · 2022Article
- Collective cell migration ofCommunications biology · 2019Article
- Extracting cellular automaton rules from physical Langevin equation models for single and collective cell migration.Journal of mathematical biology · 2017Article
- Protein-mediated interactions of pancreatic islet cells.Scientifica · 2013Review
- Live cell flattening - traditional and novel approaches.PMC biophysics · 2010Article
- Calcium waves.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2008Review
- An anatomy ontology to represent biological knowledge in Dictyostelium discoideum.BMC genomics · 2008Article
- Direct mechanical force measurements during the migration of Dictyostelium slugs using flexible substrata.Biophysical journal · 2005Article
- How cellular movement determines the collective force generated by the Dictyostelium discoideum slug.Journal of theoretical biology · 2004Article
- Cell movements and mechanical force distribution during the migration of dictyostelium slugs.Journal of biological physics · 2004Article
- A model for individual and collective cell movement in Dictyostelium discoideum.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Light affects cAMP signaling and cell movement activity in Dictyostelium discoideum.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
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1 author.
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Abstract
In the development of the cellular slime mold Dictyostelium discoideum there is a stage in which the aggregated amoebae form a migrating slug that moves forward in a polar fashion, showing sensitive orientation to environmental cues, as well as early signs of differentiation into anterior prestalk and posterior prespore cells. Heretofore it has been difficult to follow the movement of the individual cells within the slug, but a new method is described in which small, flat (one cell thick) slugs are produced in a glass-mineral oil interface where one can follow the movement of all the cells. Observations of time-lapse videos reveal the following facts about slug migration: (i) While the posterior cells move straight forward, the anterior cells swirl about rapidly in a chaotic fashion. (ii) Turning involves shifting the high point of these hyperactive cells. (iii) Both the anterior and the posterior cells move forward on their own power as the slug moves forward. (iv) There are no visible regular oscillations within the slug. (v) The number of prestalk and prespore cells is proportional for a range of sizes of these mini-slugs. All of these observations on thin slugs are consistent with what one finds in normal, three-dimensional slugs.
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