ArticleProceedings of the National Academy of Sciences of the United States of America1998
Short-term regulation of insulin gene transcription by glucose.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 104 citations in OpenAlex.
- Article
- Beta cell-specific PAK1 enrichment ameliorates diet-induced glucose intolerance in mice by promoting insulin biogenesis and minimising beta cell apoptosis.Diabetologia · 2025Article
- Targeting pancreatic β cells for diabetes treatment.Nature metabolism · 2022Review
- Differential expression of aerobic oxidative metabolism-related proteins in diabetic urinary exosomes.Frontiers in endocrinology · 2022Article
- Insulin: The Friend and the Foe in the Development of Type 2 Diabetes Mellitus.International journal of molecular sciences · 2020Review
- RNA-seq-based identification of Star upregulation by islet amyloid formation.Protein engineering, design & selection : PEDS · 2019Article
- ANutrition research and practice · 2018Article
- PKCδ inhibition normalizes the wound-healing capacity of diabetic human fibroblasts.The Journal of clinical investigation · 2016Article
- Effects of Tocotrienols on Insulin Secretion-Associated Genes Expression of Rat Pancreatic Islets in a Dynamic Culture.Frontiers in pharmacology · 2016Article
- Differences in insulin biosynthesis pathway between small and large islets do not correspond to insulin secretion.Islets · 2015Article
- Article
- miR-25 and miR-92a regulate insulin I biosynthesis in rats.RNA biology · 2013Article
- Glucagon regulates its own synthesis by autocrine signaling.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Article
- Glucose regulates free cytosolic Zn²⁺ concentration, Slc39 (ZiP), and metallothionein gene expression in primary pancreatic islet β-cells.The Journal of biological chemistry · 2011Article
- Nucleo-cytosolic shuttling of FoxO1 directly regulates mouse Ins2 but not Ins1 gene expression in pancreatic beta cells (MIN6).The Journal of biological chemistry · 2011Article
- Characterization of immortalized mesenchymal stem cells derived from foetal porcine pancreas.Cell proliferation · 2011Article
- The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction.Molecular endocrinology (Baltimore, Md.) · 2010Article
- Insulin expressed from endogenously active glucose-responsive EGR1 promoter in bone marrow mesenchymal stromal cells as diabetes therapy.Gene therapy · 2010Article
- Microassay for glucose-induced preproinsulin mRNA expression to assess islet functional potency for islet transplantation.Transplantation · 2010Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whereas short-term regulation of insulin biosynthesis at the level of translation is well accepted, glucose-dependent transcriptional control is still believed to be a long-term effect occurring after more than 2 hr of glucose stimulation. Because pancreatic beta cells are exposed to elevated glucose levels for minutes rather than hours after food uptake, we hypothesized the existence of a short-term transcriptional control. By studying the dynamics of newly synthesized (prepro)insulin RNA and by employing on-line monitoring of gene expression in single, insulin-producing cells, we were able to provide convincing evidence that insulin gene transcription indeed is affected by glucose within minutes. Exposure of insulinoma cells and isolated pancreatic islets to elevated glucose for only 15 min resulted in a 2- to 5-fold elevation in (prepro)insulin mRNA levels within 60-90 min. Similarly, insulin promoter-driven green fluorescent protein expression in single insulin-producing cells was significantly enhanced after transient glucose stimulation. Thus, short-term signaling, such as that involved in insulin secretion, also may regulate insulin gene transcription.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.