ArticleThe EMBO journal1998
E1A directly binds and regulates the P/CAF acetyltransferase.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 123 citations in OpenAlex.
- Adenovirus 5 E1A Interacts with E4orf3 To Regulate Viral Chromatin Organization.Journal of virology · 2019Article
- Transcriptomic and proteomic analyses reveal new insights into the regulation of immune pathways during adenovirus type 2 infection.BMC microbiology · 2019Article
- Competitive Inhibition of Lysine Acetyltransferase 2B by a Small Motif of the Adenoviral Oncoprotein E1A.The Journal of biological chemistry · 2016Article
- p300/CBP histone acetyltransferase activity is required for newly acquired and reactivated fear memories in the lateral amygdala.Learning & memory (Cold Spring Harbor, N.Y.) · 2013Article
- Epigenetic regulation of the IL-13-induced human eotaxin-3 gene by CREB-binding protein-mediated histone 3 acetylation.The Journal of biological chemistry · 2011Article
- Acetylation and nuclear receptor action.The Journal of steroid biochemistry and molecular biology · 2011Review
- The N terminus of adenovirus type 12 E1A inhibits major histocompatibility complex class I expression by preventing phosphorylation of NF-kappaB p65 Ser276 through direct binding.Journal of virology · 2010Article
- The adenoviral E1A protein displaces corepressors and relieves gene repression by unliganded thyroid hormone receptors in vivo.Cell research · 2009Article
- Requirements for E1A dependent transcription in the yeast Saccharomyces cerevisiae.BMC molecular biology · 2009Article
- Inhibition of transcriptional activation and cell proliferation activities of adenovirus E1A by the unique N-terminal domain of CtBP2.Oncogene · 2008Article
- Intrinsic structural disorder in adenovirus E1A: a viral molecular hub linking multiple diverse processes.Journal of virology · 2008Review
- Conditionally replicating adenoviruses for cancer treatment.Current cancer drug targets · 2007Review
- Relationship between E1A binding to cellular proteins, c-myc activation and S-phase induction.Oncogene · 2007Article
- Involvement of chromatin and histone deacetylation in SV40 T antigen transcription regulation.Nucleic acids research · 2007Article
- A cancer-specific transcriptional signature in human neoplasia.The Journal of clinical investigation · 2005Article
- Recruitment of CBP/p300, TATA-binding protein, and S8 to distinct regions at the N terminus of adenovirus E1A.Journal of virology · 2005Article
- Use of adenoviral E1A protein to analyze K18 promoter deregulation in colon carcinoma cells discloses a role for CtBP1 and BRCA1.BMC molecular biology · 2005Article
- Acetylation regulates the differentiation-specific functions of the retinoblastoma protein.The EMBO journal · 2004Article
- Adenovirus E1B 55-kilodalton oncoprotein binds to Daxx and eliminates enhancement of p53-dependent transcription by Daxx.Journal of virology · 2003Article
- Strategic attack on host cell gene expression during adenovirus infection.Journal of virology · 2003Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The P/CAF protein has intrinsic histone acetyltransferase (HAT) activity and is capable of binding the transcriptional co-activator CBP. Here we show that P/CAF can regulate transcription and that this function is independent of its binding to CBP. The HAT domain of P/CAF has transcriptional activation potential in yeast. In mammalian cells P/CAF can stimulate transcription of the RSV promoter, using the activity of its HAT domain. We show that the adenovirus protein E1A targets P/CAF and sequesters its transcriptional activity. Binding of E1A to P/CAF is direct, independent of CBP and requires residues within E1A conserved region 1. We find that the P/CAF binding residues in E1A are within a motif shown to be essential for efficient disruption of myogenesis by E1A. The fact that E1A can directly bind and regulate the activity of P/CAF, independently of its regulation of CBP, highlights an important role for P/CAF in the process of cell differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.