ArticleThe EMBO journal1998
Response regulator output in bacterial chemotaxis.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.
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Who cites it
106 citing papers in PubMed, 230 citations in OpenAlex.
- The dynamic response of the bacterial flagellar motor to its direct intracellular input signal.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The E. coli escape wave in response to external ZnBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- Active transport of a passive colloid in a bath of run-and-tumble particles.Scientific reports · 2024Article
- Flagellar dynamics reveal fluctuations and kinetic limit in the Escherichia coli chemotaxis network.Scientific reports · 2023Article
- Silver Ions Inhibit Bacterial Movement and Stall Flagellar Motor.International journal of molecular sciences · 2023Article
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- Size limits the sensitivity of kinetic schemes.Nature communications · 2023Article
- Individual-Based Modeling of Spatial Dynamics of Chemotactic Microbial Populations.ACS synthetic biology · 2022Article
- Transitioning to confined spaces impacts bacterial swimming and escape response.Biophysical journal · 2022Article
- The Response Regulator FlmD Regulates Biofilm Formation inMicroorganisms · 2022Article
- Role of Position K+4 in the Phosphorylation and Dephosphorylation Reaction Kinetics of the CheY Response Regulator.Biochemistry · 2021Article
- Collective motion enhances chemotaxis in a two-dimensional bacterial swarm.Biophysical journal · 2021Article
- Article
- Direct Mapping from Intracellular Chemotaxis Signaling to Single-Cell Swimming Behavior.Biophysical journal · 2020Article
- Robustness in an Ultrasensitive Motor.mBio · 2020Article
- Blue Light Is a Universal Signal forJournal of bacteriology · 2019Article
- Plasmid-encoded protein attenuates Escherichia coli swimming velocity and cell growth, not reprogrammed regulatory functions.Biotechnology progress · 2019Article
- Single-particle tracking discloses binding-mediated rocking diffusion of rod-shaped biological particles on lipid membranes.Chemical science · 2019Article
- Signal Transduction Proteins inFrontiers in microbiology · 2019Review
- Recent Advances in the Systems Biology of Aging.Antioxidants & redox signaling · 2018Review
46 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Chemotaxis responses in Escherichia coli are mediated by the phosphorylated response-regulator protein P-CheY. Biochemical and genetic studies have established the mechanisms by which the various components of the chemotaxis system, the membrane receptors and Che proteins function to modulate levels of CheY phosphorylation. Detailed models have been formulated to explain chemotaxis sensing in quantitative terms; however, the models cannot be adequately tested without knowledge of the quantitative relationship between P-CheY and bacterial swimming behavior. A computerized image analysis system was developed to collect extensive statistics on freeswimming and individual tethered cells. P-CheY levels were systematically varied by controlled expression of CheY in an E.coli strain lacking the CheY phosphatase, CheZ, and the receptor demethylating enzyme CheB. Tumbling frequency was found to vary with P-CheY concentration in a weakly sigmoidal fashion (apparent Hill coefficient approximately 2.5). This indicates that the high sensitivity of the chemotaxis system is not derived from highly cooperative interactions between P-CheY and the flagellar motor, but rather depends on nonlinear effects within the chemotaxis signal transduction network. The complex relationship between single flagella rotation and free-swimming behavior was examined; our results indicate that there is an additional level of information processing associated with interactions between the individual flagella. An allosteric model of the motor switching process is proposed which gives a good fit to the observed switching induced by P-CheY. Thus the level of intracellular P-CheY can be estimated from behavior determinations: approximately 30% of the intracellular pool of CheY appears to be phosphorylated in fully adapted wild-type cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.