ReviewJournal of inherited metabolic disease1998
The human arginases and arginase deficiency.
Review in Journal of inherited metabolic disease, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 158 citations in OpenAlex.
- ACMG/AMP variant classification framework in arginase 1 deficiency: Implications for birth prevalence estimates and diagnostics.Genetics in medicine open · 2024Article
- L-arginine homeostasis governs adult neural stem cell activation by modulating energy metabolism in vivo.The EMBO journal · 2023Article
- Outdoor particulate matter exposure affects metabolome in chronic obstructive pulmonary disease: Preliminary study.Frontiers in public health · 2023Article
- Arginase deficiency in Bulgaria: first cases and potential endemic region for the disorder.Journal of genetics · 2023Article
- Construction of a transposase accessible chromatin landscape reveals chromatin state of repeat elements and potential causal variant for complex traits in pigs.Journal of animal science and biotechnology · 2022Article
- Arginase 1 deficiency presenting as complicated hereditary spastic paraplegia.Cold Spring Harbor molecular case studies · 2022Article
- Natural history of arginase 1 deficiency and the unmet needs of patients: A systematic review of case reports.JIMD reports · 2022Article
- Intermittent lipid nanoparticle mRNA administration prevents cortical dysmyelination associated with arginase deficiency.Molecular therapy. Nucleic acids · 2022Article
- Erythrocyte sphingolipid species as biomarkers of Alzheimer's disease.Journal of pharmaceutical analysis · 2022Article
- Recent Advances in Understanding of Alzheimer's Disease Progression through Mass Spectrometry-Based Metabolomics.Phenomics (Cham, Switzerland) · 2022Article
- Arginase 2 and Polyamines in Human Pancreatic Beta Cells: Possible Role in the Pathogenesis of Type 2 Diabetes.International journal of molecular sciences · 2021Review
- Integrative Analysis of Transcriptome-Wide Association Study and mRNA Expression Profiles Identified Candidate Genes and Pathways Associated With Acute Myocardial Infarction.Frontiers in genetics · 2021Article
- Respiratory Alkalosis in Neurodegenerative Disorder.Indian journal of pediatrics · 2020Article
- Hepatic arginase deficiency fosters dysmyelination during postnatal CNS development.JCI insight · 2019Article
- Human hepatocyte transplantation corrects the inherited metabolic liver disorder arginase deficiency in mice.Molecular genetics and metabolism · 2018Article
- Argininemia as a cause of severe chronic stunting and partial growth hormone deficiency (PGHD): A case report.Medicine · 2018Article
- Long-term dietary restriction up-regulates activity and expression of renal arginase II in aging mice.Journal of biosciences · 2017Article
- Proof-of-Concept Gene Editing for the Murine Model of Inducible Arginase-1 Deficiency.Scientific reports · 2017Article
- Liver-specific knockout of arginase-1 leads to a profound phenotype similar to inducible whole body arginase-1 deficiency.Molecular genetics and metabolism reports · 2016Article
- Argininemia as a cause of severe chronic stunting in a low-resource developing country setting: a case report.BMC pediatrics · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Arginase is the final enzyme in the urea cycle. Its deficiency is the least frequently described disorder of this cycle. It results primarily in elevated blood arginine, and less frequently in either persistent or acute elevations in blood ammonia. This appears to be due to a second arginase locus, expressed primarily in the kidney, which can be recruited to compensate, in part, for the deficiency of liver arginase. The liver arginase gene structure permitted study of the molecular pathology of patients with the disorder and the results of these studies and the inferences about the protein structure are presented. The conserved regions among all arginases allowed the cloning of AII, the second arginase isoform. It has been localized to the mitochondrion and is thought to be involved in ornithine biosynthesis. It shares the major conserved protein sequences, and structural features of liver arginase gene are also conserved. When AI and AII from various species are compared, it appears that the two diverged some time prior to the evolution of amphibians. The evidence for the role of AII in nitric oxide and polyamine metabolism is presented and this appears consonant with the data on the tissue distribution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.