ArticleNucleic acids research1998
Cloning, chromosomal localization and promoter analysis of the human transcription factor YY1.
Article in Nucleic acids research, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 49 citations in OpenAlex.
- Yin Yang 1: Function, Mechanisms, and Glia.Neurochemical research · 2025Review
- Article
- Effect of the transcription factor YY1 on the development of pancreatic endocrine and exocrine tumors: a narrative review.Cell & bioscience · 2021Review
- The biological implications of Yin Yang 1 in the hallmarks of cancer.Theranostics · 2020Review
- Article
- Expression of YY1 correlates with progression and metastasis in esophageal squamous cell carcinomas.OncoTargets and therapy · 2014Article
- Betulinic acid targets YY1 and ErbB2 through cannabinoid receptor-dependent disruption of microRNA-27a:ZBTB10 in breast cancer.Molecular cancer therapeutics · 2012Article
- Yin Yang 1 contains G-quadruplex structures in its promoter and 5'-UTR and its expression is modulated by G4 resolvase 1.Nucleic acids research · 2012Article
- Article
- Molecular characterization and transcriptional analysis of the olive flounder (Paralichthys olivaceus) YGHL1 gene in response to hypoxia and infection.Molecular and cellular biochemistry · 2011Article
- Transcription regulator Yin-yang 1: from silence to cancer.Critical reviews in oncogenesis · 2011Article
- Analysis of Alzheimer's disease severity across brain regions by topological analysis of gene co-expression networks.BMC systems biology · 2010Article
- Regulation of the transcription factor YY1 in mitosis through phosphorylation of its DNA-binding domain.Molecular biology of the cell · 2009Article
- YY1 is autoregulated through its own DNA-binding sites.BMC molecular biology · 2009Article
- The Yin and Yang of YY1 in the nervous system.Journal of neurochemistry · 2008Review
- The combined immunodetection of AP-2alpha and YY1 transcription factors is associated with ERBB2 gene overexpression in primary breast tumors.Breast cancer research : BCR · 2008Article
- Differential regulation of human YY1 and caspase 7 promoters by prohibitin through E2F1 and p53 binding sites.The Biochemical journal · 2007Article
- Transcription factor YY1: structure, function, and therapeutic implications in cancer biology.Oncogene · 2006Review
- Targeted disruption of mouse Yin Yang 1 transcription factor results in peri-implantation lethality.Molecular and cellular biology · 1999Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Yin Yang 1 (YY1) is a protein that activates and represses transcription of a large number of cellular and viral genes. In addition, studies suggest that YY1 may play an important role in development and differentiation. Here, we report the isolation and analysis of a YY1 genomic clone from a lambda human liver library. Fluorescence in situ hybridization with the YY1 clone has localized the YY1 gene to chromosome 14 band q32. A major YY1 gene transcription initiation site has been mapped to 478 bp upstream of the ATG translation start site. The proximal promoter contains multiple Sp1 transcription factor binding sites but lacks a consensus TATA or CCAAT box. Transient transfections and detailed deletion analyses localized the promoter to no more than 277 bp upstream from the major transcription start site. Finally, we have found that overexpression of the adenovirus E1A protein represses expression of a reporter gene directed by the YY1 promoter.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.