ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences1998
Aspects of the biology of regeneration and repair in the human gastrointestinal tract.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 73 citations in OpenAlex.
- Review
- Signaling Pathways in the Pathogenesis of Barrett's Esophagus and Esophageal Adenocarcinoma.International journal of molecular sciences · 2023Review
- CCR6 activation links innate immune responses to mucosa-associated lymphoid tissue lymphoma development.Haematologica · 2022Article
- Cellular Plasticity, Reprogramming, and Regeneration: Metaplasia in the Stomach and Beyond.Gastroenterology · 2022Review
- Trefoil Factor Family (TFF) Peptides and Their Links to Inflammation: A Re-evaluation and New Medical Perspectives.International journal of molecular sciences · 2021Review
- Role of metaplasia during gastric regeneration.American journal of physiology. Cell physiology · 2020Review
- Trefoil Factor Family (TFF) Peptides and Their Diverse Molecular Functions in Mucus Barrier Protection and More: Changing the Paradigm.International journal of molecular sciences · 2020Review
- The metaplastic mosaic of Barrett's oesophagus.Virchows Archiv : an international journal of pathology · 2018Review
- CD44 variant isoform 9 emerges in response to injury and contributes to the regeneration of the gastric epithelium.The Journal of pathology · 2017Article
- Role of vitamin DBMC gastroenterology · 2016Article
- The Development of Spasmolytic Polypeptide/TFF2-Expressing Metaplasia (SPEM) During Gastric Repair Is Absent in the Aged Stomach.Cellular and molecular gastroenterology and hepatology · 2016Article
- TFF Peptides Play a Role in the Immune Response Following Oral Infection of Mice with Toxoplasma Gondii.European journal of microbiology & immunology · 2015Article
- [Barrett's esophagus: analyses from human and experimental animal studies].Der Pathologe · 2013Article
- Knowledge translation: airway epithelial cell migration and respiratory diseases.Cellular and molecular life sciences : CMLS · 2012Review
- Epithelial restitution and wound healing in inflammatory bowel disease.World journal of gastroenterology · 2008Review
- Effect of electroacupunture on gastric mucosal intestinal trefoil factor gene expression of stress-induced gastric mucosal injury in rats.World journal of gastroenterology · 2006Article
- The gastrointestinal tract stem cell niche.Stem cell reviews · 2006Review
- Cyclooxygenase 2, pS2, inducible nitric oxide synthase and transforming growth factor alpha in gastric adaptation to stress.World journal of gastroenterology · 2004Article
- Role of TFF in healing of stress-induced gastric lesions.World journal of gastroenterology · 2003Article
- Preventive effect of hydrotalcite on gastric mucosal injury in rats induced by taurocholate.World journal of gastroenterology · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The main pathways of epithelial differentiation in the intestine, Paneth, mucous, endocrine and columnar cell lineages are well recognized. However, in abnormal circumstances, for example in mucosal ulceration, a cell lineage with features distinct from these emerges, which has often been dismissed in the past as 'pyloric' metaplasia, because of its morphological resemblance to the pyloric mucosa in the stomach. However, we can conclude that this cell lineage has a defined phenotype unique in gastrointestinal epithelia, has a histogenesis that resembles that of Brunner's glands, but acquires a proliferative organization similar to that of the gastric gland. It expresses several peptides of particular interest, including epidermal growth factor, the trefoil peptides TFF1, TFF2, TFF3, lysozyme and PSTI. The presence of this lineage also appears to cause altered gene expression in adjacent indigenous cell lineages. We propose that this cell lineage is induced in gastrointestinal stem cells as a result of chronic mucosal ulceration, and plays an important part in ulcer healing; it should therefore be added to the repertoire of gastrointestinal stem cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.