ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences1998
Wound healing in the liver with particular reference to stem cells.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Expression and significance of histone methyltransferase SET domain containing 2 with histone H3 lysine 36 trimethylation in mouse hepatic oval cells differentiated into bile duct epithelial cellsMolecular medicine reports · 2023Article
- Negligible Oval Cell Proliferation Following Ischemia-Reperfusion Injury With and Without Partial Hepatectomy.Ochsner journal · 2017Article
- Regenerative medicine: Hepatic progenitor cells up their game in the therapeutic stakes.Nature reviews. Gastroenterology & hepatology · 2015Article
- Stem cells in liver regeneration and their potential clinical applications.Stem cell reviews and reports · 2013Review
- Trefoil factor 3 as an endocrine neuroprotective factor from the liver in experimental cerebral ischemia/reperfusion injury.PloS one · 2013Article
- The role of stem cells in liver repair and fibrosis.The international journal of biochemistry & cell biology · 2011Review
- Hepatic fibrosis is enhanced and accompanied by robust oval cell activation after chronic carbon tetrachloride administration to Egr-1-deficient mice.The American journal of pathology · 2010Article
- Liver cancer: the role of stem cells.Cell proliferation · 2005Review
- Liver stem cells: implications for hepatocarcinogenesis.Stem cell reviews · 2005Review
- Characterization and enrichment of hepatic progenitor cells in adult rat liver.World journal of gastroenterology · 2004Article
- Hepatic stem cells: from inside and outside the liver?Cell proliferation · 2004Review
- Listeria monocytogenes mutants that fail to compartmentalize listerolysin O activity are cytotoxic, avirulent, and unable to evade host extracellular defenses.Infection and immunity · 2003Article
- Hepatic microenvironment affects oval cell localization in albumin-urokinase-type plasminogen activator transgenic mice.The American journal of pathology · 2003Article
- Heterogeneity of ductular reactions in adult rat and human liver revealed by novel expression of deleted in malignant brain tumor 1.The American journal of pathology · 2002Article
- Molecular regulation of hepatocyte generation in adult animals.The American journal of pathology · 2002Review
- Stem cell and precursor cell therapy.Neuromolecular medicine · 2002Review
- Control of life, death, and differentiation in cultured midgut cells of the lepidopteran, Heliothis virescens.In vitro cellular & developmental biology. Animal · 2001Article
- Cellular origin of regenerating parenchyma in a mouse model of severe hepatic injury.The American journal of pathology · 2000Article
- Modulation of the gene network connected to interferon-gamma in liver regeneration from oval cells.The American journal of pathology · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The efficiency of liver regeneration in response to the loss of hepatocytes is widely acknowledged, and this is usually accomplished by the triggering of normally proliferatively quiescent hepatocytes into the cell cycle. However, when regeneration is defective, tortuous ductular structures, initially continuous with the biliary tree, proliferate and migrate into the surrounding hepatocyte parenchyma. In humans, these biliary cells have variously been referred to as ductular structures, neoductules and neocholangioles, and have been observed in many forms of chronic liver disease, including cancer. In experimental animals, similar ductal cells are usually called oval cells, and their association with impaired regeneration has led to the conclusion that they are the progeny of facultative stem cells. Oval cells are of considerable biological interest as they may represent a target population for hepatic carcinogens, and they may also be useful vehicles for ex vivo gene therapy for the correction of inborn errors of metabolism. This review proposes that the liver harbours stem cells that are located in the biliary epithelium, that oval cells are the progeny of these stem cells, and that these cells can undergo massive expansion in their numbers before differentiating into hepatocytes. This is a conditional process that only occurs when the regenerative capacity of hepatocytes is overwhelmed, and thus, unlike the intestinal epithelium, the liver is not behaving as a classical, continually renewing, stem cell-fed lineage. We focus on the biliary network, not merely as a conduit for bile, but also as a cell compartment with the ability to proliferate under appropriate conditions and give rise to fully differentiated hepatocytes and other cell types.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.