ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences1998
Epithelial carcinogenesis in the mouse: correlating the genetics and the biology.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Can tissue biomarkers be used to determine the prognosis of oral leukoplakia lesions with regards to malignant transformation?Evidence-based dentistry · 2022Article
- Delineating Molecular Mechanisms of Squamous Tissue Homeostasis and Neoplasia: Focus on p63.Journal of skin cancer · 2013Article
- Skin squamous cell carcinoma propagating cells increase with tumour progression and invasiveness.The EMBO journal · 2012Article
- Establishment and characterization of an osteopontin-null cutaneous squamous cell carcinoma cell line.In vitro cellular & developmental biology. Animal · 2010Article
- Targeted disruption of stat3 reveals a major role for follicular stem cells in skin tumor initiation.Cancer research · 2009Article
- PAI-1 Regulates the Invasive Phenotype in Human Cutaneous Squamous Cell Carcinoma.Journal of oncology · 2009Article
- Article
- A signaling pathway involving TGF-beta2 and snail in hair follicle morphogenesis.PLoS biology · 2005Article
- Article
- Expression of both TNF-alpha receptor subtypes is essential for optimal skin tumour development.Oncogene · 2004Article
- High incidence of epithelial cancers in mice deficient for DNA polymerase delta proofreading.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- CCAAT/enhancer binding protein-beta is a mediator of keratinocyte survival and skin tumorigenesis involving oncogenic Ras signaling.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Proliferation, cell cycle and apoptosis in cancer.Nature · 2001Review
- Molecular cloning and sequence analysis of the promoter region of mouse cyclin D1 gene: implication in phorbol ester-induced tumour promotion.Cell proliferation · 2000Article
- Lineage selection and the evolution of multistage carcinogenesis.Proceedings. Biological sciences · 1999Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumour formation relies on a complex combination of genetic and environmental factors. In particular, the contributions from inherited predisposition genes as well as carcinogens, for example from cigarettes or in the diet, are amongst the major contributors to tumorigenesis. Since the study of such processes in particularly difficult in human cancers, the availability of a well-defined model system is of obvious benefit. The mouse skin model of multistage carcinogenesis offers an excellent tool for the study of the target cells, the target genes and the biological events associated with neoplasia. In this system, tumorigenesis occurs in a series of defined stages, each of which is characterized by specific and reproducible alterations in genes such as H-ras, cyclin D1, p53 and p16INK4A. Additional changes occur in the production of, or response to, factors such as transforming growth factor beta (TGF beta). These genetic and biological alterations are mirrored in human tumours of epithelial origin. Hence, research into the general principles of tumour initiation, promotion and progression in the context of the mouse skin model is likely to prove valuable in the continual search for new methods for the diagnosis, prevention, and therapeutic treatment of human cancers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.