ArticleCanadian journal of veterinary research = Revue canadienne de recherche veterinaire1998
Lesions and distribution of viral antigen following an experimental infection of young seronegative calves with virulent bovine virus diarrhea virus-type II.
Article in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 111 citations in OpenAlex.
- Effect on hematopoietic tissue of experimental infection of calves with noncytopathic type 2 bovine viral diarrhea virus.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2004Trial
- Platelet aggregation responses and virus isolation from platelets in calves experimentally infected with type I or type II bovine viral diarrhea virus.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2001Trial
- Comparative efficacy of modified-live and inactivated vaccines in boosting disease-sparing responses to bovine viral diarrhea virus challenge in neonatally mucosally primed weanling beef calves.The Canadian veterinary journal = La revue veterinaire canadienne · 2023Article
- Benzimidazole-2-Phenyl-Carboxamides as Dual-Target Inhibitors of BVDV Entry and Replication.Viruses · 2022Article
- Article
- Bovine viral diarrhea virus: An updated American College of Veterinary Internal Medicine consensus statement with focus on virus biology, hosts, immunosuppression, and vaccination.Journal of veterinary internal medicine · 2020Article
- Sequential exposure to bovine viral diarrhea virus and bovine coronavirus results in increased respiratory disease lesions: clinical, immunologic, pathologic, and immunohistochemical findings.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2020Article
- Transcriptome analysis reveals differential immune related genes expression in bovine viral diarrhea virus-2 infected goat peripheral blood mononuclear cells (PBMCs).BMC genomics · 2019Article
- Experimental infection of mice with noncytopathic bovine viral diarrhea virus 2 increases the number of megakaryocytes in bone marrow.Virology journal · 2018Article
- Virulent Properties of Russian Bovine Viral Diarrhea Virus Strains in Experimentally Infected Calves.Scientifica · 2016Article
- Acute BVDV-2 infection in beef calves delays humoral responses to a non-infectious antigen challenge.The Canadian veterinary journal = La revue veterinaire canadienne · 2015Article
- Description of the first acute bovine diarrhea virus-2 outbreak in Israel.Veterinary journal (London, England : 1997) · 2011Article
- Immunofluorescence analysis of duck plague virus gE protein on DPV-infected ducks.Virology journal · 2011Article
- Pathogenesis and pathology of bovine pneumonia.The Veterinary clinics of North America. Food animal practice · 2010Review
- Detection of inhibition of bovine viral diarrhea virus by aromatic cationic molecules.Antimicrobial agents and chemotherapy · 2003Article
- Coinfection with bovine viral diarrhea virus and Mycoplasma bovis in feedlot cattle with chronic pneumonia.The Canadian veterinary journal = La revue veterinaire canadienne · 2002Article
- Screening of neonatal calves for persistent infection with bovine viral diarrhea virus by immunohistochemistry on skin biopsy samples.Clinical and diagnostic laboratory immunology · 2002Article
- The immunohistochemical detection of Mycoplasma bovis and bovine viral diarrhea virus in tissues of feedlot cattle with chronic, unresponsive respiratory disease and/or arthritis.The Canadian veterinary journal = La revue veterinaire canadienne · 2001Article
- The immunology of the bovine respiratory disease complex.The Veterinary clinics of North America. Food animal practice · 2001Review
- Perspectives for the treatment of infections with Flaviviridae.Clinical microbiology reviews · 2000Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the past several years, acute infections with bovine viral diarrhea virus (BVDV) have been causally linked to hemorrhagic and acute mucosal disease-like syndromes with high mortality. The majority of BVDVs isolated in such cases have been classified as type II on the basis of genetic and antigenic characteristics. It was our objective to examine clinical disease, lesions and potential sites of viral replication, following experimental BVDV type II infection in young calves. On approximately day 35 after birth, calves that had received BVDV-antibody-negative colostrum were infected by intranasal inoculation of 5 x 10(5) TCID50 of BVDV type II isolate 24,515 in 5 mL of tissue culture fluid (2.5 mL/nostril). Calves were monitored twice daily for signs of clinical disease. Approximately 48-72 h after infection, all calves developed transient pyrexia (39.4-40.5 degrees C) and leukopenia. Beginning on approximately day 7 after infection, all calves developed watery diarrhea, pyrexia (40.5-41.6 degrees C), marked leukopenia (> or = 75% drop from preinoculation values), variable thrombocytopenia, and moderate to severe depression. Calves were euthanized on days 10, 11, or 12 after infection due to severe disease. Gross and histological lesions consisted of multifocal bronchointerstitial pneumonia (involving 10%-25% of affected lungs), bone marrow hypoplasia and necrosis, and minimal erosive lesions in the alimentary tract. Immunohistochemical staining for BVDV revealed widespread viral antigen usually within epithelial cells, smooth muscle cells and mononuclear phagocytes in multiple organs, including lung, Peyer's patches, gastric mucosa, thymus, adrenal gland, spleen, lymph nodes, bone marrow, and skin. This BVDV type II isolate caused rapidly progressive, severe multisystemic disease in seronegative calves that was associated with widespread distribution of viral antigen and few gross or histological inflammatory lesions.
Indexed as
Identifiers
9684044PMC1189471W304703020What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.