ArticleAmerican journal of human genetics1998
Commitment to X inactivation precedes the twinning event in monochorionic MZ twins.
Article in American journal of human genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 137 citations in OpenAlex.
- The transcriptional legacy of developmental stochasticity.Nature communications · 2023Article
- Investigation of the role of X chromosome inactivation and androgen receptor CAG repeat polymorphisms in patients with recurrent pregnancy loss: a prospective case-control study.BMC pregnancy and childbirth · 2022Article
- Variability of cross-tissue X-chromosome inactivation characterizes timing of human embryonic lineage specification events.Developmental cell · 2022Article
- Autoimmunity in women: an eXClinical immunology (Orlando, Fla.) · 2020Review
- Chorionicity and Heritability Estimates from Twin Studies: The Prenatal Environment of Twins and Their Resemblance Across a Large Number of Traits.Behavior genetics · 2016Article
- Increased serotonin transporter gene (SERT) DNA methylation is associated with bullying victimization and blunted cortisol response to stress in childhood: a longitudinal study of discordant monozygotic twins.Psychological medicine · 2013Article
- New insights into genotype-phenotype correlations for the doublecortin-related lissencephaly spectrum.Brain : a journal of neurology · 2013Article
- Article
- Expression of the disease on female carriers of X-linked lysosomal disorders: a brief review.Orphanet journal of rare diseases · 2010Review
- X chromosome inactivation in clinical practice.Human genetics · 2009Review
- Female monozygotic twins discordant for hemophilia A due to nonrandom X-chromosome inactivation.American journal of hematology · 2008Article
- X-chromosome inactivation patterns in monozygotic twins and sib pairs discordant for nonsyndromic cleft lip and/or palate.American journal of medical genetics. Part A · 2007Article
- Increased DNA methylation at the AXIN1 gene in a monozygotic twin from a pair discordant for a caudal duplication anomaly.American journal of human genetics · 2006Article
- A longitudinal study of X-inactivation ratio in human females.Human genetics · 2004Article
- The role of X-chromosome inactivation in female predisposition to autoimmunity.Arthritis research · 2000Article
- Genetics of rheumatoid arthritis: confronting complexity.Arthritis research · 1999Review
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To gain insight into the timing of twinning, we have examined a closely related event, X-chromosome inactivation, in female MZ twin pairs. X-inactivation patterns in peripheral blood and buccal mucosa were compared between monochorionic MZ (MC-MZ) and dichorionic MZ (DC-MZ) twins. Overall, the MC-MZ twins displayed highly similar X-inactivation patterns, whereas DC-MZ twins frequently differed in their X-inactivation patterns, when both tissues were tested. Previous experimental data suggest that commitment to X inactivation occurs when there are 10-20 cells in the embryo. Simulation of embryo splitting after commitment to X inactivation suggests that MC-MZ twinning occurs three or four rounds of replication after X inactivation, whereas a DC-MZ twinning event occurs earlier, before or around the time of X inactivation. Finally, the overall degree of skewing in the MZ twins was not significantly different from that observed in singletons. This indicates that X inactivation does not play a direct role in the twinning process, and it further suggests that extreme unequal splitting is not a common mechanism of twin formation.
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