ArticleAmerican journal of human genetics1998
Haplotype structure and population genetic inferences from nucleotide-sequence variation in human lipoprotein lipase.
Article in American journal of human genetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005209 (Genetic Epidemiology of Coronary Heart Disease), which is not on this map. Cited by 126 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic Epidemiology of Coronary Heart Disease
Who cites it
126 citing papers in PubMed, 439 citations in OpenAlex.
- Linkage Disequilibrium, Haplotype Block Structures, Effective Population Size and Genome-Wide Signatures of Selection of Two Conservation Herds of the South African Nguni Cattle.Animals : an open access journal from MDPI · 2022Article
- MethHaplo: combining allele-specific DNA methylation and SNPs for haplotype region identification.BMC bioinformatics · 2020Article
- The Relationship Between Haplotype-BasedGenetics · 2019Article
- Haplotypes of CYP1B1 and CCDC57 genes in an Afro-Caribbean female population with uterine leiomyoma.Molecular biology reports · 2019Article
- A New Fast Phasing Method Based On Haplotype Subtraction.The Journal of molecular diagnostics : JMD · 2019Article
- Powerful testing via hierarchical linkage disequilibrium in haplotype association studies.Biometrical journal. Biometrische Zeitschrift · 2019Article
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- Single nucleotide polymorphism (SNP)-strings: an alternative method for assessing genetic associations.PloS one · 2014Article
- Population genetic analysis of Lobelia rhynchopetalum Hemsl. (Campanulaceae) using DNA sequences from ITS and eight chloroplast DNA regions.TheScientificWorldJournal · 2012Article
- Improved risk prediction for Crohn's disease with a multi-locus approach.Human molecular genetics · 2011Article
- The application and performance of single nucleotide polymorphism markers for population genetic analyses of lepidoptera.Frontiers in genetics · 2011Article
- On the use of cartographic projections in visualizing phylo-genetic tree space.Algorithms for molecular biology : AMB · 2010Article
- Malaria severity and human nitric oxide synthase type 2 (NOS2) promoter haplotypes.Human genetics · 2010Article
- A new association test to test multiple-marker association.Genetic epidemiology · 2009Article
- Linkage disequilibrium--understanding the evolutionary past and mapping the medical future.Nature reviews. Genetics · 2008Review
- Worldwide distribution of NAT2 diversity: implications for NAT2 evolutionary history.BMC genetics · 2008Article
- Algorithms to estimate the lower bounds of recombination with or without recurrent mutations.BMC genomics · 2008Article
- Direct maximum parsimony phylogeny reconstruction from genotype data.BMC bioinformatics · 2007Article
- Understanding the accuracy of statistical haplotype inference with sequence data of known phase.Genetic epidemiology · 2007Article
66 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
Abstract
Allelic variation in 9.7 kb of genomic DNA sequence from the human lipoprotein lipase gene (LPL) was scored in 71 healthy individuals (142 chromosomes) from three populations: African Americans (24) from Jackson, MS; Finns (24) from North Karelia, Finland; and non-Hispanic Whites (23) from Rochester, MN. The sequences had a total of 88 variable sites, with a nucleotide diversity (site-specific heterozygosity) of .002+/-.001 across this 9.7-kb region. The frequency spectrum of nucleotide variation exhibited a slight excess of heterozygosity, but, in general, the data fit expectations of the infinite-sites model of mutation and genetic drift. Allele-specific PCR helped resolve linkage phases, and a total of 88 distinct haplotypes were identified. For 1,410 (64%) of the 2,211 site pairs, all four possible gametes were present in these haplotypes, reflecting a rich history of past recombination. Despite the strong evidence for recombination, extensive linkage disequilibrium was observed. The number of haplotypes generally is much greater than the number expected under the infinite-sites model, but there was sufficient multisite linkage disequilibrium to reveal two major clades, which appear to be very old. Variation in this region of LPL may depart from the variation expected under a simple, neutral model, owing to complex historical patterns of population founding, drift, selection, and recombination. These data suggest that the design and interpretation of disease-association studies may not be as straightforward as often is assumed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.