ArticleJournal of bacteriology1998
Lack of consistent short sequence repeat polymorphisms in genetically homologous colonizing and invasive Candida albicans strains.
Article in Journal of bacteriology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- Candida identification: a journey from conventional to molecular methods in medical mycology.World journal of microbiology & biotechnology · 2014Review
- Molecular fingerprints to identify Candida species.BioMed research international · 2013Review
- National surveillance of fungemia in Denmark (2004 to 2009).Journal of clinical microbiology · 2011Article
- Molecular analysis of Candida albicans isolates from clinical specimens.Mycopathologia · 2010Article
- Comparative genomics and molecular dynamics of DNA repeats in eukaryotes.Microbiology and molecular biology reviews : MMBR · 2008Review
- Microsatellite DNA identification and genotyping of Candida albicans from Lebanese clinical isolates.Mycopathologia · 2008Article
- Assessment of Candida glabrata strain relatedness by pulsed-field gel electrophoresis and multilocus sequence typing.Journal of clinical microbiology · 2007Article
- New microsatellite multiplex PCR for Candida albicans strain typing reveals microevolutionary changes.Journal of clinical microbiology · 2005Article
- Use of a novel panel of nine short tandem repeats for exact and high-resolution fingerprinting of Aspergillus fumigatus isolates.Journal of clinical microbiology · 2005Article
- Use of variable-number tandem repeats to examine genetic diversity of Neisseria meningitidis.Journal of clinical microbiology · 2005Article
- Detection and selection of microsatellites in the genome of Paracoccidioides brasiliensis as molecular markers for clinical and epidemiological studies.Journal of clinical microbiology · 2004Article
- Analysis of microsatellites in 13 hemiascomycetous yeast species: mechanisms involved in genome dynamics.Journal of molecular evolution · 2003Article
- Highly polymorphic microsatellite for identification of Candida albicans strains.Journal of clinical microbiology · 2003Article
- Analysis of microsatellite markers of Candida albicans used for rapid typing.Journal of clinical microbiology · 2001Article
- Differentiation of strains of Xylella fastidiosa by a variable number of tandem repeat analysis.Applied and environmental microbiology · 2001Article
- Microsatellite typing as a new tool for identification of Saccharomyces cerevisiae strains.Journal of clinical microbiology · 2001Article
- Comparative genotyping of Candida albicans bloodstream and nonbloodstream isolates at a polymorphic microsatellite locus.Journal of clinical microbiology · 2000Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Short sequence repeats (SSRs), potentially representing variable numbers of tandem repeat (VNTR) loci, were identified for the human-pathogenic yeast species Candida albicans by computerized DNA sequence scanning. The individual SSR regions were investigated in different clinical isolates of C. albicans. Most of the C. albicans SSRs were identified as genuine VNTRs. They appeared to be present in multiple allelic variants and were demonstrated to be diverse in length among nonrelated strains. As such, these loci provide adequate targets for the molecular typing of C. albicans strains. VNTRs encountered in other microbial species sometimes participate in regulation of gene expression and function as molecular switches at the transcriptional or translational level. Interestingly, the VNTRs identified here often encode polyglutamine stretches and are frequently located within genes potentially involved in the regulation of transcription. DNA sequencing of these VNTRs demonstrated that the length variability was restricted to the CAA/CAG repeats encoding the polyglutamine stretches. For these reasons, paired C. albicans isolates of similar genotype, either found as noninvasive colonizers or encountered in an invasive state in the same individual, were studied with respect to potentially invasion-related alterations in the VNTR profiles. However, none of the VNTRs analyzed thus far varied systematically with the transition from colonization to invasion. In contrast to the situation described for some prokaryotic species, this finding suggests that VNTRs of C. albicans may not simply function as contingency loci related to straightforward on/off regulation of invasion-related gene expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.