ArticleThe Journal of physiology1998
Mechanosensitive cation channels mediate afferent arteriolar myogenic constriction in the isolated rat kidney.
Article in The Journal of physiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
- Vascular mechanotransduction.Physiological reviews · 2023Review
- Kidney physiology and pathophysiology during heat stress and the modification by exercise, dehydration, heat acclimation and aging.Temperature (Austin, Tex.) · 2021Review
- Can Myogenic Tone Protect Endothelial Function? Integrating Myogenic Activation and Dilator Reactivity for Cerebral Resistance Arteries in Metabolic Disease.Journal of vascular research · 2021Article
- Regional heterogeneity in the mechanisms of myogenic tone in hamster arterioles.American journal of physiology. Heart and circulatory physiology · 2017Article
- Renal autoregulation in health and disease.Physiological reviews · 2015Review
- Calcium dynamics underlying the myogenic response of the renal afferent arteriole.American journal of physiology. Renal physiology · 2014Article
- Genes that confer the identity of the renin cell.Journal of the American Society of Nephrology : JASN · 2011Article
- Pressure induces intracellular calcium changes in juxtaglomerular cells in perfused afferent arterioles.Hypertension research : official journal of the Japanese Society of Hypertension · 2011Article
- Canonical TRP channels and mechanotransduction: from physiology to disease states.Pflugers Archiv : European journal of physiology · 2010Review
- Enhanced myogenic response in the afferent arteriole of spontaneously hypertensive rats.American journal of physiology. Heart and circulatory physiology · 2010Article
- Effect of epithelial sodium channel blockade on the myogenic response of rat juxtamedullary afferent arterioles.Hypertension (Dallas, Tex. : 1979) · 2009Article
- TRP channels and mechanosensory transduction: insights into the arterial myogenic response.Pflugers Archiv : European journal of physiology · 2008Review
- Effects of arterial wall stress on vasomotion.Biophysical journal · 2006Article
- A hypertonicity-activated nonselective conductance in single proximal tubule cells isolated from mouse kidney.The Journal of membrane biology · 2003Article
- Measurement of chloride flux associated with the myogenic response in rat cerebral arteries.The Journal of physiology · 2001Article
- An intracellular ATP-activated, calcium-permeable conductance on the basolateral membrane of single renal proximal tubule cells isolated from Rana temporaria.The Journal of physiology · 2000Article
- Mechanosensitive cation channels mediate afferent arteriolar myogenic constriction in the isolated rat kidney.The Journal of physiology · 1998Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. In order to assess ionic mechanisms mediating renal afferent arteriolar myogenic constriction, experiments were performed using isolated perfused hydronephrotic rat kidneys. 2. Increasing pressure progressively constricted the afferent arteriole (-0.26 +/- 0.02% mmHg-1, n = 21, r = 0.97). Gadolinium (10 microM), a mechanosensitive cation channel blocker, abolished this myogenic constriction. However, high potassium media (30 mM) constricted the afferent arteriole in the presence of gadolinium. 3. Lowering extracellular sodium concentration gradually attenuated afferent arteriolar myogenic constriction. In the perfusate containing 50 mM sodium, the myogenic response was arrested. 4. Afferent arteriolar myogenic constriction was prevented in calcium-free perfusate or by the L-type calcium channel blocker diltiazem (10 microM). 5. Our present findings provide evidence that increasing pressure gates mechanosensitive cation channels on the afferent arteriole, thereby eliciting membrane depolarization and activating voltage-dependent calcium channels.
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