ArticleThe Journal of physiology1998
Contribution of sarcoplasmic reticular calcium to smooth muscle contractile activation: gestational dependence in isolated rat uterus.
Article in The Journal of physiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 96 citations in OpenAlex.
- EMMIs: Engineered Myometrial Microtissues for Direct Quantification of Oxytocin-Induced Contractility.bioRxiv : the preprint server for biology · 2026Article
- Uterine contractions in rodent models and humans.Acta physiologica (Oxford, England) · 2021Review
- A computational model of excitation and contraction in uterine myocytes from the pregnant rat.Scientific reports · 2018Article
- Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development.Journal of visualized experiments : JoVE · 2018Article
- Seipin deficiency leads to defective parturition in mice.Biology of reproduction · 2017Article
- Ryanodine receptor type 3 does not contribute to contractions in the mouse myometrium regardless of pregnancy.Pflugers Archiv : European journal of physiology · 2017Article
- The effects of Ginseng Java root extract on uterine contractility in nonpregnant rats.Physiological reports · 2014Article
- Store-operated Ca²⁺ entry and depolarization explain the anomalous behaviour of myometrial SR: effects of SERCA inhibition on electrical activity, Ca²⁺ and force.Cell calcium · 2014Article
- Ryanodine receptors are uncoupled from contraction in rat vena cava.Cell calcium · 2013Article
- A close look at the contraction and relaxation of the myometrium; the role of calcium.Journal of the Turkish German Gynecological Association · 2013Review
- From structure to function: mitochondrial morphology, motion and shaping in vascular smooth muscle.Journal of vascular research · 2013Review
- Mitochondrial regulation of cytosolic Ca²⁺ signals in smooth muscle.Pflugers Archiv : European journal of physiology · 2012Review
- Role of mitochondria in contraction and pacemaking in the mouse uterus.British journal of pharmacology · 2010Article
- A functional role for nicotinic acid adenine dinucleotide phosphate in oxytocin-mediated contraction of uterine smooth muscle from rat.The Journal of pharmacology and experimental therapeutics · 2010Article
- Ryanodine receptor type 2 deficiency changes excitation-contraction coupling and membrane potential in urinary bladder smooth muscle.The Journal of physiology · 2007Article
- Regulation of the uterine contractile apparatus and cytoskeleton.Seminars in cell & developmental biology · 2007Review
- A role for voltage-gated, but not Ca2+-activated, K+ channels in regulating spontaneous contractile activity in myometrium from virgin and pregnant rats.British journal of pharmacology · 2006Article
- Lipid rafts, the sarcoplasmic reticulum and uterine calcium signalling: an integrated approach.The Journal of physiology · 2006Review
- The role of the sarcoplasmic reticulum in neonatal uterine smooth muscle: enhanced role compared to adult rat.The Journal of physiology · 2002Article
- Phospholamban regulation of bladder contractility: evidence from gene-altered mouse models.The Journal of physiology · 2001Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
1. The contribution of Ca2+ released from the sarcoplasmic reticulum (SR) to smooth muscle contractile activation remains poorly understood. By simultaneously monitoring cytosolic [Ca2+] ([Ca2+]i) and force in isolated rat uterine smooth muscle, we report the influence of SR Ca2+ release on contractility during conditions (a) of altered SR Ca2+ homeostasis and (b) where the only source of activating Ca2+ was derived from the SR. 2. In myometria of non-pregnant rats, ryanodine (1-50 microM), a modulator of calcium-induced calcium release (CICR), had no effect on the spontaneous [Ca2+]i or force transients. However, depletion of SR Ca2+ by inhibiting the SR Ca2+-ATPase (with cyclopiazonic acid (CPA), 20 microM) resulted in an enhancement of spontaneous [Ca2+]i and force transients. 3. In myometria of pregnant rats, although ryanodine had no effect in 40% of tissues studied it produced a small but significant enhancement of the integrated spontaneous [Ca2+]i and force transient in 60% of cases. The potentiating effects of CPA were enhanced in myometria of pregnant rats compared with non-pregnant rats, often resulting in maintained [Ca2+]i increases and contraction. 4. In zero external Ca2+, agonist-induced SR Ca2+ release resulted in transient increases in [Ca2+]i and force. The magnitude of these agonist-induced [Ca2+]i and force changes were significantly enhanced in myometria of pregnant rats. No evidence for agonist-induced Ca2+-independent force production was observed. 5. These results indicate that CICR plays little role in SR Ca2+ release from the myometrium, and that there are gestational-dependent alterations in the ability of SR Ca2+ mobilization to contribute to contractile activation. The implications of these findings for the co-ordination of myometrial [Ca2+]i signalling and contractility are discussed.
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