ArticleThe Journal of cell biology1998
Iqg1p, a yeast homologue of the mammalian IQGAPs, mediates cdc42p effects on the actin cytoskeleton.
Article in The Journal of cell biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
44 citing papers in PubMed, 94 citations in OpenAlex.
- Review
- A Flow Cytometry-Based Phenotypic Screen To Identify Novel Endocytic Factors inG3 (Bethesda, Md.) · 2018Article
- The WW domain of the scaffolding protein IQGAP1 is neither necessary nor sufficient for binding to the MAPKs ERK1 and ERK2.The Journal of biological chemistry · 2017Article
- IQGAP1: insights into the function of a molecular puppeteer.Molecular immunology · 2015Review
- The biology of IQGAP proteins: beyond the cytoskeleton.EMBO reports · 2015Review
- A molecular rheostat at the interface of cancer and diabetes.Biochimica et biophysica acta · 2013Review
- Inhibition of Cdc42 during mitotic exit is required for cytokinesis.The Journal of cell biology · 2013Article
- Timing it right: precise ON/OFF switches for Rho1 and Cdc42 GTPases in cytokinesis.The Journal of cell biology · 2013Article
- Separate roles of IQGAP Rng2p in forming and constricting the Schizosaccharomyces pombe cytokinetic contractile ring.Molecular biology of the cell · 2013Article
- Plasma membrane growth during the cell cycle: unsolved mysteries and recent progress.Current opinion in cell biology · 2012Review
- A calcium-dependent interaction between calmodulin and the calponin homology domain of human IQGAP1.Molecular and cellular biochemistry · 2012Article
- Cdk1-dependent control of membrane-trafficking dynamics.Molecular biology of the cell · 2012Article
- A conserved role of IQGAP1 in regulating TOR complex 1.Journal of cell science · 2012Article
- Biochemical analysis of the interactions of IQGAP1 C-terminal domain with CDC42.World journal of biological chemistry · 2012Article
- IQ-motif selectivity in human IQGAP2 and IQGAP3: binding of calmodulin and myosin essential light chain.Bioscience reports · 2011Article
- Single and multiple CH (calponin homology) domain containing multidomain proteins in Arabidopsis and Saccharomyces: an inventory.Molecular biology reports · 2011Article
- Evolution of the Ras-like small GTPases and their regulators.Small GTPases · 2011Article
- Involvement of the cytoskeleton in controlling leading-edge function during chemotaxis.Molecular biology of the cell · 2010Article
- An emerging role for IQGAP1 in regulating protein traffic.TheScientificWorldJournal · 2010Review
- IQGAP1 regulates cell proliferation through a novel CDC42-mTOR pathway.Journal of cell science · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The Rho-type GTPase Cdc42p has been implicated in diverse cellular functions including cell shape, cell motility, and cytokinesis, all of which involve the reorganization of the actin cytoskeleton. Targets of Cdc42p that interface the actin cytoskeleton are likely candidates for mediating cellular activities. In this report, we identify and characterize a yeast homologue for the mammalian IQGAP, a cytoskeletal target for Cdc42p. The yeast IQGAP homologue, designated Iqg1p, displays a two-hybrid interaction with activated Cdc42p and coimmunoprecipitates with actin filaments. Deletion of IQG1 results in a temperature-sensitive lethality and causes aberrant morphologies including elongated and round multinucleated cells. This together with its localization at the mother-bud neck, suggest that Iqg1p promotes budding and cytokinesis. At restrictive temperatures, the vacuoles of the mutant cells enlarge and vesicles accumulate in the bud. Interestingly, Iqg1p shows two-hybrid interactions with the ankyrin repeat-containing protein, Akr1p (Kao, L.-R., J. Peterson, J. Ruiru, L. Bender, and A. Bender. 1996. Mol. Cell. Biol. 16:168-178), which inhibits pheromone signaling and appears to promote cytokinesis and/or trafficking. We also show two-hybrid interactions between Iqg1p and Afr1p, a septin-binding protein involved in projection formation (Konopka, J.B., C. DeMattei, and C. Davis. 1995. Mol. Cell. Biol. 15:723-730). We propose that Iqg1p acts as a scaffold to recruit and localize a protein complex involved in actin-based cellular functions and thus mediates the regulatory effects of Cdc42p on the actin cytoskeleton.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.