ArticleThe Journal of cell biology1998
The cytosolic DnaJ-like protein djp1p is involved specifically in peroxisomal protein import.
Article in The Journal of cell biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 84 citations in OpenAlex.
- Proteins that carry dual targeting signals can act as tethers between peroxisomes and partner organelles.PLoS biology · 2024Article
- Proteomic consequences of TDA1 deficiency in Saccharomyces cerevisiae: Protein kinase Tda1 is essential for Hxk1 and Hxk2 serine 15 phosphorylation.Scientific reports · 2022Article
- Partial dispensability of Djp1's J domain in peroxisomal protein import in Saccharomyces cerevisiae results from genetic redundancy with another class II J protein, Caj1.Cell stress & chaperones · 2017Article
- Article
- Isolation and characterization of a J domain protein that interacts with ARC1 from ornamental kale (Brassica oleracea var. acephala).Plant cell reports · 2015Article
- The role of Djp1 in import of the mitochondrial protein Mim1 demonstrates specificity between a cochaperone and its substrate protein.Molecular and cellular biology · 2013Article
- Synthetic lethal interactions in yeast reveal functional roles of J protein co-chaperones.Molecular bioSystems · 2012Article
- Pex3-anchored Atg36 tags peroxisomes for degradation in Saccharomyces cerevisiae.The EMBO journal · 2012Article
- A novel family of dehydrin-like proteins is involved in stress response in the human fungal pathogen Aspergillus fumigatus.Molecular biology of the cell · 2011Article
- Peroxisomal membrane proteins insert into the endoplasmic reticulum.Molecular biology of the cell · 2010Article
- Arabidopsis thaliana J-class heat shock proteins: cellular stress sensors.Functional & integrative genomics · 2009Review
- Hsp70 structure, function, regulation and influence on yeast prions.Protein and peptide letters · 2009Review
- Identification and functional characterization of Arabidopsis PEROXIN4 and the interacting protein PEROXIN22.The Plant cell · 2005Article
- Role for the Ran binding protein, Mog1p, in Saccharomyces cerevisiae SLN1-SKN7 signal transduction.Eukaryotic cell · 2004Article
- The J-protein family: modulating protein assembly, disassembly and translocation.EMBO reports · 2004Review
- Lessons from the genome sequence of Neurospora crassa: tracing the path from genomic blueprint to multicellular organism.Microbiology and molecular biology reviews : MMBR · 2004Review
- Opinion: peroxisomal-protein import: is it really that complex?Nature reviews. Molecular cell biology · 2002Review
- Oxidative stress and acclimation mechanisms in plants.The arabidopsis book · 2002Article
- A role for Vps1p, actin, and the Myo2p motor in peroxisome abundance and inheritance in Saccharomyces cerevisiae.The Journal of cell biology · 2001Article
- Saccharomyces cerevisiae PTS1 receptor Pex5p interacts with the SH3 domain of the peroxisomal membrane protein Pex13p in an unconventional, non-PXXP-related manner.Molecular biology of the cell · 2000Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Saccharomyces cerevisiae DJP1 gene encodes a cytosolic protein homologous to Escherichia coli DnaJ. DnaJ homologues act in conjunction with molecular chaperones of the Hsp70 protein family in a variety of cellular processes. Cells with a DJP1 gene deletion are viable and exhibit a novel phenotype among cytosolic J-protein mutants in that they have a specific impairment of only one organelle, the peroxisome. The phenotype was also unique among peroxisome assembly mutants: peroxisomal matrix proteins were mislocalized to the cytoplasm to a varying extent, and peroxisomal structures failed to grow to full size and exhibited a broad range of buoyant densities. Import of marker proteins for the endoplasmic reticulum, nucleus, and mitochondria was normal. Furthermore, the metabolic adaptation to a change in carbon source, a complex multistep process, was unaffected in a DJP1 gene deletion mutant. We conclude that Djp1p is specifically required for peroxisomal protein import.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.