ArticleBiophysical journal1998
Optical recording system based on a fiber optic image conduit: assessment of microscopic activation patterns in cardiac tissue.
Article in Biophysical journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Optical mapping of contracting hearts.The Journal of physiology · 2023Review
- Optical recording of calcium currents during impulse conduction in cardiac tissue.Neurophotonics · 2015Article
- Optical mapping in the developing zebrafish heart.Pediatric cardiology · 2012Review
- A protective antiarrhythmic role of ursodeoxycholic acid in an in vitro rat model of the cholestatic fetal heart.Hepatology (Baltimore, Md.) · 2011Article
- A fiber-based ratiometric optical cardiac mapping channel using a diffraction grating and split detector.Biophysical journal · 2007Article
- Optical imaging and functional characterization of the transverse tubular system of mammalian muscle fibers using the potentiometric indicator di-8-ANEPPS.The Journal of membrane biology · 2005Article
- Ionic currents involved in shock-induced nonlinear changes in transmembrane potential responses of single cardiac cells.Pflugers Archiv : European journal of physiology · 2004Article
- Spatial heterogeneity of transmembrane potential responses of single guinea-pig cardiac cells during electric field stimulation.The Journal of physiology · 2002Article
- Intramural multisite recording of transmembrane potential in the heart.Biophysical journal · 2001Article
- High-speed, random-access fluorescence microscopy: II. Fast quantitative measurements with voltage-sensitive dyes.Biophysical journal · 1999Article
- Cell cultures as models of cardiac mechanoelectric feedback.Progress in biophysics and molecular biologyReview
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Optical recording of transmembrane voltage changes with the use of potentiometric dyes has opened the possibility of determining spatial patterns of electrical activity in excitable tissues. To follow such activation patterns on the cellular/subcellular level in heart cell cultures, a recording system was developed that features both high spatial resolution (4-200 microm) and high temporal resolution (uncertainty in the determination of delays between fast rising signals of +/-1 micros). Central to the system is a fiber optic image conduit consisting of 379 individual optical fibers. At one end the fibers are fused to form an input window that matches the size of the field of view of the microscope. At the other end, the fibers are loose, permitting a selectable subset to be connected to 80 discrete photodetectors. This design allows the sensitive area of the imager to be adapted to regions of interest in a given preparation, thus making optimal use of the limited number of detectors. Furthermore, by using a second fiber optic imager, individual photodetectors can be assigned to different optical ports, thus providing the means for fast and simultaneous dual-emission wavelength measurements. This feature permitted the elimination of motion artifacts arising from the myocytes without the use of contraction-suppressing drugs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.