ReviewClinical pharmacokinetics1998
Pharmacokinetic and pharmacodynamic changes in the elderly. Clinical implications.
Review in Clinical pharmacokinetics, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 4 syntheses or guidelines pooled it, 272 citations in OpenAlex.
- Population Pharmacokinetics of Levetiracetam: A Systematic Review.Clinical pharmacokinetics · 2021Pooled it
- Demographic Characteristics of Participants in Rheumatoid Arthritis Randomized Clinical Trials: A Systematic Review.JAMA network open · 2019Pooled it
- A review of factors explaining variability in fentanyl pharmacokinetics; focus on implications for cancer patients.British journal of clinical pharmacology · 2017Pooled it
- Population pharmacokinetics of orally administered duloxetine in patients: implications for dosing recommendation.Clinical pharmacokinetics · 2009Pooled it
- Steady-state pharmacokinetics and bioavailability of immediate-release and extended-release formulations of lamotrigine in elderly epilepsy patients: Use of stable isotope methodology.Journal of clinical pharmacology · 2015Trial
- Effect of age on the pharmacokinetics of duloxetine in women.British journal of clinical pharmacology · 2004Trial
- Influence of age on the pharmacokinetics and pharmacodynamics of ximelagatran, an oral direct thrombin inhibitor.Clinical pharmacokinetics · 2003Trial
- Influence of age and cytochrome P450 2C9 genotype on the steady-state disposition of diclofenac and celecoxib.Clinical pharmacokinetics · 2003Trial
- Impact of aging on the pharmacokinetic profile of everolimus in male mice.BMC pharmacology & toxicology · 2026Article
- Patterns and determinants of drug-drug interactions among community-dwelling older adults in Saudi Arabia: a cross-sectional study.Frontiers in pharmacology · 2026Article
- Circadian system and aging: where both times interact.Frontiers in aging · 2025Review
- Comparative study of the pharmacokinetics, efficacy and safety of ET-26 in elderly and non-elderly subjects: the results of a phase I clinical trial.Frontiers in pharmacology · 2025Article
- Complex Psychotropic Polypharmacy in Soweto-based community psychiatry clinics.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2025Article
- Aqueous-humor biomarkers and real-world efficacy of conbercept for diabetic macular edema: a prospective study in elderly patients.Frontiers in endocrinology · 2025Article
- Clinical pearls for the management of duloxetine patients with medical comorbidities.The mental health clinician · 2024Article
- Anthracyclines-Induced Cardiac Dysfunction: What Every Clinician Should Know.Reviews in cardiovascular medicine · 2023Review
- Age-related modifications in CYP-dependent drug metabolism: role of stress.Frontiers in endocrinology · 2023Review
- The association between benzodiazepine use and greater risk of neurocognitive impairment is moderated by medical burden in people with HIV.Journal of neurovirology · 2022Article
- Development of a physiologically based pharmacokinetic (PBPK) population model for Chinese elderly subjects.British journal of clinical pharmacology · 2021Article
- Exploring instruments used to evaluate potentially inappropriate medication use in hospitalised elderly patients in Kosovo.European journal of hospital pharmacy : science and practice · 2021Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Age-related changes in pharmacokinetics principally affect drug absorption, distribution, metabolism and elimination. Changes in pharmacodynamics are primarily seen in the cardiovascular and neuroendocrine system. Age-dependent changes in the kinetics and dynamics of drugs acting on the cardiovascular system and central nervous system are common, and this review, while by no means exhaustive of the effects of drugs on all organ systems, is reflective of the principles and gives examples of the effects of age on these 2 major systems. While pharmacokinetic changes in the elderly are usually well characterised, pharmacodynamic changes are understood only in the most preliminary way. There has been relatively little research in this area of geriatric clinical pharmacology, and pharmacodynamic changes are still an area of investigation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.