ArticleInfection and immunity1998
Interleukin-9 enhances resistance to the intestinal nematode Trichuris muris.
Article in Infection and immunity, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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Who cites it
68 citing papers in PubMed, 150 citations in OpenAlex.
- Schistosomiasis vaccine SchistoShield® induces functional immune memory responses in US and African populations.NPJ vaccines · 2026Article
- Dynamics of Interleukin-9 Producing Lymphocytes inPathogens (Basel, Switzerland) · 2026Article
- Characterization of microRNA Expression Profiles of Murine Female Genital Tracts FollowingMicroorganisms · 2025Article
- Neuroinflammation and Amyotrophic Lateral Sclerosis: Recent Advances in Anti-Inflammatory Cytokines as Therapeutic Strategies.International journal of molecular sciences · 2025Review
- Metabolic regulation of Th9 cell differentiation: insights for IL-9-driven diseases.Frontiers in immunology · 2025Review
- Partial Protection of Goats againstVaccines · 2024Article
- Pumpkin seeds (Cucurbita pepo subsp. ovifera) decoction promotes Trichinella spiralis expulsion during intestinal phase via "Weep and Sweep" mechanism.Scientific reports · 2024Article
- The World according to IL-9.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Identification of excretory and secretory proteins from Haemonchus contortus inducing a Th9 immune response in goats.Veterinary research · 2022Article
- Mast cell tissue heterogeneity and specificity of immune cell recruitment.Frontiers in immunology · 2022Review
- The Framework for Human Host Immune Responses to Four Types of Parasitic Infections and Relevant Key JAK/STAT Signaling.International journal of molecular sciences · 2021Review
- Review
- Trichuris muris infection drives cell-intrinsic IL4R alpha independent colonic RELMα+ macrophages.PLoS pathogens · 2021Article
- The role of βBMC immunology · 2021Article
- Cytokine changes in fatal cases of paraquat poisoning.American journal of translational research · 2021Article
- Unveiling the Immunomodulatory Characteristics ofAnimals : an open access journal from MDPI · 2020Article
- Immunomodulatory dynamics of excretory and secretory products on Th9 immune response during Haemonchus contortus infection in goat.PLoS neglected tropical diseases · 2020Article
- Galectin Domain Containing Protein fromBiomolecules · 2020Article
- Immunity to Soil-Transmitted Helminths: Evidence From the Field and Laboratory Models.Frontiers in immunology · 2020Review
- Establishment and Characterization of a Murine Mucosal Mast Cell Culture Model.International journal of molecular sciences · 2019Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Upon infection with the cecum-dwelling nematode Trichuris muris, the majority of inbred strains of mice launch a Th2-type immune response and in doing so expel the parasite before patency. In contrast, there are a few mouse strains which develop a nonprotective Th1-type response resulting in a chronic infection and the presence of adult worms. Of the Th2 cytokines known to be associated with the resistant phenotype (interleukin-4 [IL-4], IL-5, IL-9, and IL-13), comparatively little is known about the contribution that IL-9 makes towards the protective immune response. In this study we demonstrate that IL-9 is expressed early during the Th2-type response and that its elevation in vivo results in the enhancement of intestinal mastocytosis and the production of both the immunoglobulin E (IgE) and IgG1 isotypes. In addition, elevated IL-9 levels in vivo facilitated the loss of T. muris from the intestine. That IL-9 is important in promoting worm expulsion was also seen following infection of IL-9-transgenic mice, which constitutively overexpress the cytokine. These animals displayed an extremely rapid, but immune mediated, expulsion of the parasite. Also evident in these animals was a pronounced intestinal mastocytosis, which was previously shown by us to be responsible for the expulsion of the related nematode Trichinella spiralis from these animals. Taken together with observations of IL-9 production following infection with other helminths, the results imply that IL-9 contributes to the general mast cell and IgE response characteristic of these infections and, more specifically, enhances resistance to T. muris.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.