ArticleInfection and immunity1998
Listeria monocytogenes stimulates mucus exocytosis in cultured human polarized mucosecreting intestinal cells through action of listeriolysin O.
Article in Infection and immunity, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 49 citations in OpenAlex.
- New understanding of gut microbiota and colorectal anastomosis leak: A collaborative review of the current concepts.Frontiers in cellular and infection microbiology · 2022Review
- Increased Listeria monocytogenes Dissemination and Altered Population Dynamics in Muc2-Deficient Mice.Infection and immunity · 2021Article
- Non-immune Traits Triggered by Blood Intake Impact Vectorial Competence.Frontiers in physiology · 2021Review
- Article
- Multifaceted Defense against Listeria monocytogenes in the Gastro-Intestinal Lumen.Pathogens (Basel, Switzerland) · 2017Review
- Article
- Interactions of Intestinal Bacteria with Components of the Intestinal Mucus.Frontiers in cellular and infection microbiology · 2017Review
- Entamoeba histolytica Cysteine Proteinase 5 Evokes Mucin Exocytosis from Colonic Goblet Cells via αvβ3 Integrin.PLoS pathogens · 2016Article
- Roles and regulation of the mucus barrier in the gut.Tissue barriers · 2015Article
- Pathogenesis of human enterovirulent bacteria: lessons from cultured, fully differentiated human colon cancer cell lines.Microbiology and molecular biology reviews : MMBR · 2013Review
- Pic, an autotransporter protein secreted by different pathogens in the Enterobacteriaceae family, is a potent mucus secretagogue.Infection and immunity · 2010Article
- Two atypical enteropathogenic Escherichia coli strains induce the production of secreted and membrane-bound mucins to benefit their own growth at the apical surface of human mucin-secreting intestinal HT29-MTX cells.Infection and immunity · 2010Article
- Biotechnological applications of Listeria's sophisticated infection strategies.Microbial biotechnology · 2008Review
- The front line of enteric host defense against unwelcome intrusion of harmful microorganisms: mucins, antimicrobial peptides, and microbiota.Clinical microbiology reviews · 2006Review
- Use of RNA interference in Drosophila S2 cells to identify host pathways controlling compartmentalization of an intracellular pathogen.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Mucin degradation mechanisms by distinct Pseudomonas aeruginosa isolates in vitro.Infection and immunity · 2003Article
- Listeria pathogenesis and molecular virulence determinants.Clinical microbiology reviews · 2001Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When the intracellular pathogen Listeria monocytogenes infects cultured human mucosecreting polarized HT29-MTX cells apically, it induces the stimulation of mucus exocytosis without cell entry. Using a set of isogenic mutants and purified listeriolysin O (LLO), we identified the L. monocytogenes thiol-activated exotoxin LLO as the agonist of mucus secretion. We demonstrated that the LLO-induced mucus exocytosis did not result from the LLO membrane-damaging activity. We found that LLO-induced mucus exocytosis is an event requiring the binding of LLO to a brush border-associated receptor and membrane oligomerization of the exotoxin. By a pharmacological approach, we demonstrated that no regulatory system or intracellular transducing signal known to be involved in control of mucin exocytosis was activated by LLO. Based on the present data, the stimulatory action of LLO on mucin exocytosis could be accounted for either by an unknown signaling system which remains to be determined or by direct action of LLO with the membrane vesicle components involved in the intracellular vesicular transport of mucins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.