ArticleInfection and immunity1998
CD1 presents antigens from a gram-negative bacterium, Haemophilus influenzae type B.
Article in Infection and immunity, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 34 citations in OpenAlex.
- Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells.The Journal of clinical investigation · 2004Article
- Antibody repertoires in infants and adults: effects of T-independent and T-dependent immunizations.Springer seminars in immunopathology · 2001Review
- CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Human CD1 is a family of nonpolymorphic major histocompatibility complex class I-like molecules capable of presenting mycobacterial lipids, including lipoarabinomannan (LAM), to double-negative (DN; CD4(-) CD8(-)) as well as CD8(+) T cells. Structural similarities between LAM and the capsular polysaccharides of gram-negative bacteria led us to consider the latter as candidate CD1 ligands. We derived two CD1-restricted DN T-cell populations which proliferated to Haemophilus influenzae type b (Hib) antigen. One T-cell population also proliferated to proteinase K-treated Hib antigen, suggesting that it recognized a nonpeptide. Our work thus expands the universe of T cell antigens to include nonpeptides distinct from mycobacterial lipids and suggests a potential role for CD1-restricted T cells in immunity to Hib.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.