ArticleNucleic acids research1998
Microsporidian Encephalitozoon cuniculi, a unicellular eukaryote with an unusual chromosomal dispersion of ribosomal genes and a LSU rRNA reduced to the universal core.
Article in Nucleic acids research, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40 citing papers in PubMed.
- Paromomycin ReducesMicroorganisms · 2022Article
- Typical structure of rRNA coding genes in diplonemids points to two independent origins of the bizarre rDNA structures of euglenozoans.BMC ecology and evolution · 2022Article
- Looking through the Lens of the Ribosome Biogenesis Evolutionary History: Possible Implications for Archaeal Phylogeny and Eukaryogenesis.Molecular biology and evolution · 2022Article
- Adaptation to genome decay in the structure of the smallest eukaryotic ribosome.Nature communications · 2022Article
- Current Therapy and Therapeutic Targets for Microsporidiosis.Frontiers in microbiology · 2022Review
- Supersized Ribosomal RNA Expansion Segments in Asgard Archaea.Genome biology and evolution · 2020Article
- Evolutionary compaction and adaptation visualized by the structure of the dormant microsporidian ribosome.Nature microbiology · 2019Article
- Muller's Ratchet and Ribosome Degeneration in the Obligate Intracellular ParasitesInternational journal of molecular sciences · 2018Article
- Error-prone protein synthesis in parasites with the smallest eukaryotic genome.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Evolution of helix formation in the ribosomal Internal Transcribed Spacer 2 (ITS2) and its significance for RNA secondary structures.Journal of molecular evolution · 2014Article
- Characterization of active ribosomal RNA harboring MITEs insertion in microsporidian Nosema bombycis genome.Parasitology research · 2013Article
- Phylogenetic characterization of a microsporidium (Nosema sp. MPr) isolated from the Pieris rapae.Parasitology research · 2012Article
- Evolutionary conservation of the ribosomal biogenesis factor Rbm19/Mrd1: implications for function.PloS one · 2012Article
- Article
- A close-up view on ITS2 evolution and speciation - a case study in the Ulvophyceae (Chlorophyta, Viridiplantae).BMC evolutionary biology · 2011Article
- The complete sequence of the smallest known nuclear genome from the microsporidian Encephalitozoon intestinalis.Nature communications · 2010Article
- Evolution of the sex-related locus and genomic features shared in microsporidia and fungi.PloS one · 2010Article
- Identification of transcriptional signals in Encephalitozoon cuniculi widespread among Microsporidia phylum: support for accurate structural genome annotation.BMC genomics · 2009Article
- Non-LTR retrotransposons in fungi.Functional & integrative genomics · 2009Article
- mRNA processing in Antonospora locustae spores.Molecular genetics and genomics : MGG · 2008Article
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8 authors.
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Abstract
Microsporidia are eukaryotic parasites lacking mitochondria, the ribosomes of which present prokaryote-like features. In order to better understand the structural evolution of rRNA molecules in microsporidia, the 5S and rDNA genes were investigated in Encephalitozoon cuniculi . The genes are not in close proximity. Non-tandemly arranged rDNA units are on every one of the 11 chromosomes. Such a dispersion is also shown in two other Encephalitozoon species. Sequencing of the 5S rRNA coding region reveals a 120 nt long RNA which folds according to the eukaryotic consensus structural shape. In contrast, the LSU rRNA molecule is greatly reduced in length (2487 nt). This dramatic shortening is essentially due to truncation of divergent domains, most of them being removed. Most variable stems of the conserved core are also deleted, reducing the LSU rRNA to only those structural features preserved in all living cells. This suggests that the E.cuniculi LSU rRNA performs only the basic mechanisms of translation. LSU rRNA phylogenetic analysis with the BASEML program favours a relatively recent origin of the fast evolving microsporidian lineage. Therefore, the prokaryote-like ribosomal features, such as the absence of ITS2, may be derived rather than primitive characters.
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