ArticleNucleic acids research1998
TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I.
Article in Nucleic acids research, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- cGAS in nucleus: The link between immune response and DNA damage repair.Frontiers in immunology · 2022Pooled it
- Tumor-associated macrophage-specific LRRFIP1 promotes M2 macrophage polarization and progression of colorectal cancer via activation of the PI3K pathway.Journal of translational medicine · 2026Article
- MeCP2: The Genetic Driver of Rett Syndrome Epigenetics.Frontiers in genetics · 2021Review
- Multifunctional Roles of the Actin-Binding Protein Flightless I in Inflammation, Cancer and Wound Healing.Frontiers in cell and developmental biology · 2020Review
- Systematic Discovery of Endogenous Human Ribonucleoprotein Complexes.Cell reports · 2019Article
- Review
- LRRFIP1 Inhibits Hepatitis C Virus Replication by Inducing Type I Interferon in Hepatocytes.Hepatitis monthly · 2015Article
- Noncoding RNAs and LRRFIP1 regulate TNF expression.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Molecular basis of DNA recognition in the immune system.Journal of immunology (Baltimore, Md. : 1950) · 2013Review
- Crystal structure of the dimeric coiled-coil domain of the cytosolic nucleic acid sensor LRRFIP1.Journal of structural biology · 2013Article
- The influence of Flightless I on Toll-like-receptor-mediated inflammation in a murine model of diabetic wound healing.BioMed research international · 2013Article
- LRRFIP2 negatively regulates NLRP3 inflammasome activation in macrophages by promoting Flightless-I-mediated caspase-1 inhibition.Nature communications · 2013Article
- Leucine-rich repeat (in Flightless I) interacting protein-1 regulates a rapid type I interferon response.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2010Article
- The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway.Nature immunology · 2010Article
- Catenin' on to nucleic acid sensing.Nature immunology · 2010Article
- Mutually exclusive interactions drive handover of mRNA from export adaptors to TAP.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- HIV-1 TAR element is processed by Dicer to yield a viral micro-RNA involved in chromatin remodeling of the viral LTR.BMC molecular biology · 2007Article
- The PMC2NT domain of the catalytic exosome subunit Rrp6p provides the interface for binding with its cofactor Rrp47p, a nucleic acid-binding protein.Nucleic acids research · 2007Article
- Interplay of Fli-I and FLAP1 for regulation of beta-catenin dependent transcription.Nucleic acids research · 2006Article
- Fliih, a gelsolin-related cytoskeletal regulator essential for early mammalian embryonic development.Molecular and cellular biology · 2002Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A northwestern screen of a CHO-K1 cell line cDNA library with radiolabelled HIV-1 TAR RNA identified a novel TAR RNA interacting protein, TRIP. The human trip cDNA was also cloned and its expression is induced by phorbol esters. The N-terminus of TRIP shows high homology to the coiled coil domain of FLAP, a protein which binds the leucine-rich repeat (LRR) of Flightless I (FLI) and the interaction of TRIP with the FLI LRR has been confirmed in vitro . TRIP does not bind single stranded DNA or RNA significantly and binds double stranded DNA weakly. In contrast, TRIP binds double stranded RNA with high affinity and two molecules of TRIP bind the TAR stem. The RNA binding domain has been identified and encompasses a lysine-rich motif. A TRIP-GFP fusion is localised in the cytoplasm and excluded from the nucleus. FLI has a C-terminal gelsolin-like domain which binds actin and therefore the association of TRIP with the FLI LRR may provide a link between the actin cytoskeleton and RNA in mammalian cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.