ArticleProceedings of the National Academy of Sciences of the United States of America1998
Clines of nuclear DNA markers suggest a largely neolithic ancestry of the European gene pool.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
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38 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association between factor V Leiden mutation and recurrent pregnancy loss in the middle east countries: a Newcastle-Ottawa meta-analysis.Archives of gynecology and obstetrics · 2020Pooled it
- Strategies to work with HLA data in human populations for histocompatibility, clinical transplantation, epidemiology and population genetics: HLA-NET methodological recommendations.International journal of immunogenetics · 2012Guideline
- Interbreeding between farmers and hunter-gatherers along the inland and Mediterranean routes of Neolithic spread in Europe.Nature communications · 2024Article
- The Association Between Schizophrenia Risk Variants and Creativity in Healthy Han Chinese Subjects.Frontiers in psychology · 2019Article
- Nicotinamide as Independent Variable for Intelligence, Fertility, and Health: Origin of Human Creative Explosions?International journal of tryptophan research : IJTR · 2019Review
- Cultural hitchhiking and competition between patrilineal kin groups explain the post-Neolithic Y-chromosome bottleneck.Nature communications · 2018Article
- Between the Baltic and Danubian Worlds: the genetic affinities of a Middle Neolithic population from central Poland.PloS one · 2015Article
- When the waves of European Neolithization met: first paleogenetic evidence from early farmers in the southern Paris Basin.PloS one · 2015Article
- Spatial and temporal simulation of human evolution. Methods, frameworks and applications.Current genomics · 2014Article
- Mitochondrial DNA from El Mirador cave (Atapuerca, Spain) reveals the heterogeneity of Chalcolithic populations.PloS one · 2014Article
- Female and male perspectives on the neolithic transition in Europe: clues from ancient and modern genetic data.PloS one · 2013Article
- Article
- Ancient DNA reveals male diffusion through the Neolithic Mediterranean route.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Immunogenetics as a tool in anthropological studies.Immunology · 2011Review
- Article
- Wave-of-advance models of the diffusion of the Y chromosome haplogroup R1b1b2 in Europe.PloS one · 2011Article
- Ancient DNA from European early neolithic farmers reveals their near eastern affinities.PLoS biology · 2010Article
- A predominantly neolithic origin for European paternal lineages.PLoS biology · 2010Article
- Craniometric data supports demic diffusion model for the spread of agriculture into Europe.PloS one · 2009Article
- The genetic legacy of religious diversity and intolerance: paternal lineages of Christians, Jews, and Muslims in the Iberian Peninsula.American journal of human genetics · 2008Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Comparisons between archaeological findings and allele frequencies at protein loci suggest that most genes of current Europeans descend from populations that have been expanding in Europe in the last 10, 000 years, in the Neolithic period. Recent mitochondrial data have been interpreted as indicating a much older, Paleolithic ancestry. In a spatial autocorrelation study at seven hypervariable loci in Europe (four microsatellites, two larger, tandem-repeat loci, and a sequence polymorphism) broad clinal patterns of DNA variation were recognized. The observed clines closely match those described at the protein level, in agreement with a possible Near Eastern origin for the ancestral population. Separation times between populations were estimated on the basis of a stepwise mutation model. Even assuming low mutation rates and long generation times, we found no evidence for population splits older than 10,000 years, with the predictable exception of Saami (Lapps). The simplest interpretation of these results is that the current nuclear gene pool largely reflects the westward and northward expansion of a Neolithic group. This conclusion is now supported by purely genetic evidence on the levels and patterns of microsatellite diversity, rather than by correlations of biological and nonbiological data. We argue that many mitochondrial lineages whose origin has been traced back to the Paleolithic period probably reached Europe at a later time.
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