ArticleProceedings of the National Academy of Sciences of the United States of America1998
Tumors of DNA mismatch repair-deficient hosts exhibit dramatic increases in genomic instability.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 37 citations in OpenAlex.
- Mutational signature analysis predicts bacterial hypermutation and multidrug resistance.Nature communications · 2025Article
- Identification of the prognostic signature based on genomic instability-related alternative splicing in colorectal cancer and its regulatory network.Frontiers in bioengineering and biotechnology · 2022Article
- Article
- A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease.Human molecular genetics · 2011Article
- Genomic instability in mouse Burkitt lymphoma is dominated by illegitimate genetic recombinations, not point mutations.Oncogene · 2002Article
- Elevated mutant frequencies and predominance of G:C to A:T transition mutations in Msh6(-/-) small intestinal epithelium.Oncogene · 2002Article
- A new mutator phenotype in breast cancer?Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Genetic instability favoring transversions associated with ErbB2-induced mammary tumorigenesis.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Multiple mutations are common at mouse Aprt in genotoxin-exposed mismatch repair deficient cells.Oncogene · 2002Article
- Genetic factors affecting the impact of DNA polymerase delta proofreading activity on mutation avoidance in yeast.Genetics · 1999Article
- Low expression of MSH2 DNA repair protein is associated with poor prognosis in head and neck squamous cell carcinoma.Journal of applied oral science : revista FOBArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA mismatch repair (MMR) deficiency is associated with an increased mutational burden and predisposition to certain malignancies. Relatively little is known, however, about gene-specific mutation frequencies within MMR-deficient primary tumors. Thymic lymphomas from Msh2(-/-) mice were thus analyzed by using a lacI-based transgenic shuttle-phage mutation detection system. All tumors exhibited greatly elevated lacI gene mutation frequencies, ranging from 3.2- to 17.4-fold above the approximately 15-fold elevations present within normal Msh2(-/-) thymi. In addition, lacI genes harboring multiple changes, including clusters of mutations, were found in thymic tumor DNA. The results suggest that an additional mutator activity, such as an error-prone DNA polymerase, leads to increased genomic instability in these MMR-deficient tumors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.