ArticleProceedings of the National Academy of Sciences of the United States of America1998
In search of a mutational hotspot.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Analysis of Mutagenesis in the Escherichia coli tdk Gene: The Nucleoid Protein HNS Is Required for a Dramatic Cisplatin-Induced Hotspot.Environmental and molecular mutagenesis · 2026Article
- Base excision repair within structure-forming repeat sequences and its impact on cancer and other diseases.NAR cancer · 2025Review
- Identification of Hot and Cold Regions for Mutagenesis in the Escherichia coli tdk Gene: A Catalog of Mutational Sites.Environmental and molecular mutagenesis · 2025Article
- Direct Measurement of 8OG Syn-Anti Flips in Mutagenic 8OG·A and Long-Range Damage-Dependent Hoogsteen Breathing Dynamics UsingThe journal of physical chemistry. B · 2024Article
- 5-Chloro-2'-deoxycytidine Induces a Distinctive High-Resolution Mutational Spectrum of Transition Mutations In Vivo.Chemical research in toxicology · 2024Article
- Genetic basis of speciation and adaptation: from loci to causative mutations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Whole-exome sequencing reveals the impact of UVA light mutagenesis in xeroderma pigmentosum variant human cells.Nucleic acids research · 2020Article
- Replisome structure suggests mechanism for continuous fork progression and post-replication repair.DNA repair · 2019Review
- Impact of DNA lesion repair, replication and formation on the mutational spectra of environmental carcinogens: Aflatoxin BDNA repair · 2018Review
- Human brain harbors single nucleotide somatic variations in functionally relevant genes possibly mediated by oxidative stress.F1000Research · 2016Article
- Determinants of spontaneous mutation in the bacterium Escherichia coli as revealed by whole-genome sequencing.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- DNA sequence context effects on the glycosylase activity of human 8-oxoguanine DNA glycosylase.The Journal of biological chemistry · 2012Article
- Sequence-dependent structural variation in DNA undergoing intrahelical inspection by the DNA glycosylase MutM.The Journal of biological chemistry · 2012Article
- Sequence-dependent variation in the reactivity of 8-Oxo-7,8-dihydro-2'-deoxyguanosine toward oxidation.Chemical research in toxicology · 2012Article
- Effect of sequence context and direction of replication on AP site bypass in Saccharomyces cerevisiae.Mutation research · 2009Article
- Oxidative damage to the promoter region of SQSTM1/p62 is common to neurodegenerative disease.Neurobiology of disease · 2009Article
- Biological properties of single chemical-DNA adducts: a twenty year perspective.Chemical research in toxicology · 2008Review
- Estimation of DNA sequence context-dependent mutation rates using primate genomic sequences.Journal of molecular evolution · 2007Article
- Genetic effects of oxidative DNA damages: comparative mutagenesis of the imidazole ring-opened formamidopyrimidines (Fapy lesions) and 8-oxo-purines in simian kidney cells.Nucleic acids research · 2006Article
- Bacteriophage T4 genome.Microbiology and molecular biology reviews : MMBR · 2003Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
In vitro selection was used to define sequence contexts that significantly enhanced the mutagenic potential of 7, 8-dihydro-8-oxoguanine (8-oxoG). Contexts that simultaneously reduced the efficiency of 8-oxoG cleavage by formamidopyrimidine DNA N-glycosylase and increased the efficiency of misincorporating A opposite the lesion by DNA polymerase were isolated from a pool of 4(8) random octanucleotide sequences. Kinetic analysis showed that the combined effects of poor repair and high miscoding resulted in 10(2)- to 10(3)-fold increase in the mutagenic potential of 8-oxoG. Furthermore, the isolated sequence contexts correlated strongly with G --> T transversion hotspots in spontaneous mutational spectra reported for the Escherichia coli lacI and human p53 and factor IX genes. We present an example directly linking the interplay between DNA repair and replication to a "high risk sequence" for base substitution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.