ArticleProceedings of the National Academy of Sciences of the United States of America1998
Telomerase reverse transcriptase genes identified in Tetrahymena thermophila and Oxytricha trifallax.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 124 citations in OpenAlex.
- TERT mRNA peaks during meiotic prophase inmicroPublication biology · 2026Article
- Telomerase expression and activity in the immortal cnidarian Hydra.Frontiers in cell and developmental biology · 2026Article
- Article
- An Overview of the Genomic Characterization of Hepatocellular Carcinoma.Journal of hepatocellular carcinoma · 2021Review
- Current Perspectives of Telomerase Structure and Function in Eukaryotes with Emerging Views on Telomerase in Human Parasites.International journal of molecular sciences · 2018Review
- The protein subunit of telomerase displays patterns of dynamic evolution and conservation across different metazoan taxa.BMC evolutionary biology · 2017Article
- Evolutionary perspectives of telomerase RNA structure and function.RNA biology · 2016Review
- Impaired telomerase activity hinders proliferation and in vitro transformation of Penaeus monodon lymphoid cells.Cytotechnology · 2016Article
- The mutational landscape of hepatocellular carcinoma.Clinical and molecular hepatology · 2015Review
- Article
- The isothiocyanate erucin abrogates telomerase in hepatocellular carcinoma cells in vitro and in an orthotopic xenograft tumour model of HCC.Journal of cellular and molecular medicine · 2014Article
- Eimeria tenella: 14-3-3 protein interacts with telomerase.Parasitology research · 2014Article
- Article
- Insights into the evolution of mammalian telomerase: platypus TERT shares similarities with genes of birds and other reptiles and localizes on sex chromosomes.BMC genomics · 2012Article
- Telomerase and telomere-associated proteins: structural insights into mechanism and evolution.Structure (London, England : 1993) · 2012Review
- Cloning and characterization of telomerase reverse transcriptase gene in Trichinella spiralis.Parasitology research · 2012Article
- Ribonucleoprotein multimers and their functions.Critical reviews in biochemistry and molecular biology · 2010Review
- Tetrahymena telomerase protein p65 induces conformational changes throughout telomerase RNA (TER) and rescues telomerase reverse transcriptase and TER assembly mutants.Molecular and cellular biology · 2010Article
- InTERTpreting telomerase structure and function.Nucleic acids research · 2010Review
- The telomerase-specific T motif is a restrictive determinant of repetitive reverse transcription by human telomerase.Molecular and cellular biology · 2010Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Telomerase reverse transcriptase (TERT) has been identified as the catalytic subunit of the chromosome end-replicating enzyme in Euplotes, yeasts, and mammals. However, it was not reported among the protein components of purified Tetrahymena telomerase, the first telomerase identified and the most thoroughly studied. It therefore seemed possible that Tetrahymena used an alternative telomerase that lacked a TERT protein. We now report the cloning and sequencing of a Tetrahymena thermophila gene whose encoded protein has the properties expected for a TERT, including large size (133 kDa), basicity (calculated pI = 10.0), and reverse transcriptase sequence motifs with telomerase-specific features. The expression of mRNA from the Tetrahymena TERT gene increases dramatically at 2-5 h after conjugation, preceding de novo addition of telomeres to macronuclear DNA molecules. We also report the cloning and sequencing of the ortholog from Oxytricha trifallax. The Oxytricha macronuclear TERT gene has no introns, whereas that of Tetrahymena has 18 introns. Sequence comparisons reveal a new amino acid sequence motif (CP), conserved among the ciliated protozoan TERTs, and allow refinement of previously identified motifs. A phylogenetic tree of the known TERTs follows the phylogeny of the organisms in which they are found, consistent with an ancient origin rather than recent transposition. The conservation of TERTs among eukaryotes supports the model that telomerase has a conserved core (TERT plus the RNA subunit), with other subunits of the holoenzyme being more variable among species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.