ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Expression of Kv1.1, a Shaker-like potassium channel, is temporally regulated in embryonic neurons and glia.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 54 citations in OpenAlex.
- Single-nucleus transcriptome analysis reveals transcriptional profiles of circadian clock and pain related genes in human and mouse trigeminal ganglion.Frontiers in neuroscience · 2023Article
- KProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Kv1.1 channels regulate early postnatal neurogenesis in mouse hippocampus via the TrkB signaling pathway.eLife · 2021Article
- Neuron-specific Kv1.1 deficiency is sufficient to cause epilepsy, premature death, and cardiorespiratory dysregulation.Neurobiology of disease · 2020Article
- Proteomic and Transcriptomic Profiling Identifies Early Developmentally Regulated Proteins inCells · 2019Article
- Developmental expression of Kv1 voltage-gated potassium channels in the avian hypothalamus.Neuroscience letters · 2016Article
- Kv1.1-dependent control of hippocampal neuron number as revealed by mosaic analysis with double markers.The Journal of physiology · 2012Article
- Increased Kv1 channel expression may contribute to decreased sIPSC frequency following chronic inhibition of NR2B-containing NMDAR.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- A retinoblastoma orthologue is a major regulator of S-phase, mitotic, and developmental gene expression in Dictyostelium.PloS one · 2012Article
- Postnatal development of A-type and Kv1- and Kv2-mediated potassium channel currents in neocortical pyramidal neurons.Journal of neurophysiology · 2011Article
- A new Kv1.2 channelopathy underlying cerebellar ataxia.The Journal of biological chemistry · 2010Article
- Structural consequences of Kcna1 gene deletion and transfer in the mouse hippocampus.Epilepsia · 2007Article
- Functional analysis of a novel potassium channel (KCNA1) mutation in hereditary myokymia.Neurogenetics · 2007Article
- A developmental switch to GABAergic inhibition dependent on increases in Kv1-type K+ currents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Hyperexcitability and reduced low threshold potassium currents in auditory neurons of mice lacking the channel subunit Kv1.1.The Journal of physiology · 2003Article
- Dendrotoxin-sensitive K(+) currents contribute to accommodation in murine spiral ganglion neurons.The Journal of physiology · 2002Article
- Transistor probes local potassium conductances in the adhesion region of cultured rat hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Voltage-activated K+ channels and membrane depolarization regulate accumulation of the cyclin-dependent kinase inhibitors p27(Kip1) and p21(CIP1) in glial progenitor cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Cyclic AMP regulates potassium channel expression in C6 glioma by destabilizing Kv1.1 mRNA.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Transient hippocampal down-regulation of Kv1.1 subunit mRNA during associative learning in rats.Learning & memory (Cold Spring Harbor, N.Y.)Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Kv1.1, a Shaker-like voltage-gated potassium channel, is strongly expressed in a variety of neurons in adult rodents, in which it appears to be involved in regulating neuronal excitability. Here we show that Kv1.1 is also expressed during embryonic development in the mouse, exhibiting two transient peaks of expression around embryonic day 9.5 (E9.5) and E14.5. Using both in situ hybridization and immunocytochemistry, we have identified several cell types and tissues that express Kv1.1 RNA and protein. At E9.5, Kv1.1 RNA and protein are detected transiently in non-neuronal cells in several regions of the early CNS, including rhombomeres 3 and 5 and ventricular zones in the mesencephalon and diencephalon. At E14.5, several cell types in both the CNS and peripheral nervous system express Kv1.1, including neuronal cells (sensory ganglia and outer aspect of cerebral hemispheres) and glial cells (radial glia, satellite cells, and Schwann cell precursors). These data show that Kv1.1 is expressed transiently in a variety of neuronal and non-neuronal cells during restricted periods of embryonic development. Although the functional roles of Kv1.1 in development are not understood, the cell-specific localization and timing of expression suggest this channel may play a role in several developmental processes, including proliferation, migration, or cell-cell adhesion.
Indexed as
Identifiers
9671659PMC6793070W2126116200What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.