ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
The K+ channel gene ether a go-go is required for the transduction of a subset of odorants in adult Drosophila melanogaster.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 32 citations in OpenAlex.
- Crustacean leg regeneration restores complex microanatomy and cell diversity.Science advances · 2022Article
- Eag1 KOxidative medicine and cellular longevity · 2017Review
- The punctate localization of rat Eag1 K+ channels is conferred by the proximal post-CNBHD region.BMC neuroscience · 2014Article
- The stimulatory Gα(s) protein is involved in olfactory signal transduction in Drosophila.PloS one · 2011Article
- Eag and HERG potassium channels as novel therapeutic targets in cancer.World journal of surgical oncology · 2010Review
- Controversy and consensus: noncanonical signaling mechanisms in the insect olfactory system.Current opinion in neurobiology · 2009Review
- Alternative splicing of the eag potassium channel gene in Drosophila generates a novel signal transduction scaffolding protein.Molecular and cellular neurosciences · 2009Article
- Block of an ether-a-go-go-like K(+) channel by imipramine rescues egl-2 excitation defects in Caenorhabditis elegans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The functional identity of an olfactory receptor neuron is determined in part by its repertoire of responses to odorants. As an approach toward understanding the contributions of particular conductances to olfactory neuron excitability and odor discrimination, we have investigated the role of the putative cyclic nucleotide-modulated K+ channel subunit encoded by the ether a go-go (eag) gene in odorant responsiveness in Drosophila melanogaster. Four independent mutant eag alleles exhibited reduced antennal sensitivity to a subset of nine odorants, all having short aliphatic side chains: ethyl butyrate (EB), propionic acid, 2-butanone, and ethyl acetate. Significantly fewer eag antennal neurons responded to EB compared with control neurons; the proportion sensitive to 2-heptanone was similar to controls. Two aspects of the character of EB-induced excitability were affected by mutations in eag. First, fewer EB-induced inhibitory responses were observed in eag mutants, and second, fewer excitatory odorant responses dependent on extracellular Ca2+ were observed. Furthermore, modulation of neuronal excitability by membrane-permeant cyclic nucleotide analogs was largely eag dependent. Focal application of high K+ saline to sensillae altered the excitability of the majority of neurons from wild-type but not eag antennae, suggesting that Eag may have a dendritic localization.
Indexed as
Identifiers
9671652PMC6793049W1954156176What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.