ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
An essential role for a small synaptic vesicle-associated phosphatidylinositol 4-kinase in neurotransmitter release.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 87 citations in OpenAlex.
- Lipids and Secretory Vesicle Exocytosis.Advances in neurobiology · 2023Article
- Altered conformation of α-synuclein drives dysfunction of synaptic vesicles in a synaptosomal model of Parkinson's disease.Cell reports · 2021Article
- Intranasal administration as a route for drug delivery to the brain: evidence for a unique pathway for albumin.The Journal of pharmacology and experimental therapeutics · 2014Article
- Cholesterol and F-actin are required for clustering of recycling synaptic vesicle proteins in the presynaptic plasma membrane.The Journal of physiology · 2014Article
- Converging levels of analysis on a genomic hotspot for psychosis: insights from 22q11.2 deletion syndrome.Neuropharmacology · 2013Review
- Role of phosphoinositides at the neuronal synapse.Sub-cellular biochemistry · 2012Review
- Membrane-trafficking sorting hubs: cooperation between PI4P and small GTPases at the trans-Golgi network.Trends in cell biology · 2011Review
- Determination of EGFR endocytosis kinetic by auto-regulatory association of PLD1 with mu2.PloS one · 2009Article
- Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4P and PtdIns(4,5)P(2).The Biochemical journal · 2009Article
- Loss of phosphatidylinositol 4-kinase 2alpha activity causes late onset degeneration of spinal cord axons.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Modulation of the transient receptor potential channel TRPA1 by phosphatidylinositol 4,5-biphosphate manipulators.Pflugers Archiv : European journal of physiology · 2008Article
- Phosphatidylinositol 3-kinase C2alpha is essential for ATP-dependent priming of neurosecretory granule exocytosis.Molecular biology of the cell · 2005Article
- Redox modulation of basal and beta-adrenergically stimulated cardiac L-type Ca(2+) channel activity by phenylarsine oxide.British journal of pharmacology · 2004Article
- Protein-lipid interactions and phosphoinositide metabolism in membrane traffic: insights from vesicle recycling in nerve terminals.Proceedings of the National Academy of Sciences of the United States of America · 2004Review
- Localization of a highly active pool of type II phosphatidylinositol 4-kinase in a p97/valosin-containing-protein-rich fraction of the endoplasmic reticulum.The Biochemical journal · 2003Article
- Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic beta cells.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Phosphatidylinositol 4-kinase type IIalpha is responsible for the phosphatidylinositol 4-kinase activity associated with synaptic vesicles.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Role of synaptotagmin in Ca2+-triggered exocytosis.The Biochemical journal · 2002Review
- Alterations in exocytosis induced by neuronal Ca2+ sensor-1 in bovine chromaffin cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Regulation of presynaptic phosphatidylinositol 4,5-biphosphate by neuronal activity.The Journal of cell biology · 2001Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Glutamate release from nerve terminals is the consequence of Ca2+-triggered fusion of small synaptic vesicles with the presynaptic plasma membrane. ATP dependence of neurotransmitter release has been suggested to be founded, in part, on phosphorylation steps preceding membrane fusion. Here we present evidence for an essential role of phosphatidylinositol phosphorylation in stimulated release of neurotransmitter glutamate from isolated nerve terminals (synaptosomes). Specifically, we show that a phosphatidylinositol 4-kinase (PtdIns 4-kinase) activity resides on nerve terminal-derived small synaptic vesicles (SSVs) and that inhibition of the PtdIns 4-kinase activity in intact synaptosomes leads to attenuation of the evoked release of glutamate. The attenuation of transmitter release is reversible and correlates with respective changes in intrasynaptosomal PtdIns 4-kinase activity. Because only the Ca2+-dependent release of glutamate is affected, regulation appears to be at the level of exocytosis. Taken together, our data imply a mandatory role for PtdIns 4-kinase and phosphoinositide products in the regulated exocytosis of SSV in mammalian nerve terminals.
Indexed as
Identifiers
9671651PMC6793044W1660139288What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.