ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1998
Cloning and functional expression of an Aplysia 5-HT receptor negatively coupled to adenylate cyclase.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 66 citations in OpenAlex.
- Genome-Wide Identification of 5-HT Receptor Gene Family in Razor ClamAnimals : an open access journal from MDPI · 2023Article
- Article
- Serotonergic modulation across sensory modalities.Journal of neurophysiology · 2020Review
- Identification, characterization, and expression analysis of a serotonin receptor involved in the reproductive process of the Pacific abalone, Haliotis discus hannai.Molecular biology reports · 2020Article
- The CaScientific reports · 2018Article
- Article
- Pharmacological characterization of a 5-HT1-type serotonin receptor in the red flour beetle, Tribolium castaneum.PloS one · 2013Article
- Attenuation of 1-(m-chlorophenyl)-biguanide induced hippocampus-dependent memory impairment by a standardised extract of Bacopa monniera (BESEB CDRI-08).Neurochemical research · 2011Article
- Identification of a serotonin receptor coupled to adenylyl cyclase involved in learning-related heterosynaptic facilitation in Aplysia.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Molecular characterization and analysis of a truncated serotonin receptor gene expressed in neural and reproductive tissues of abalone.Histochemistry and cell biology · 2009Article
- Mechanisms regulating ApTrkl, a Trk-like receptor in Aplysia sensory neurons.Journal of neuroscience research · 2008Article
- Conservation of structure, signaling and pharmacology between two serotonin receptor subtypes from decapod crustaceans, Panulirus interruptus and Procambarus clarkii.The Journal of experimental biology · 2008Article
- Altering cAMP levels within a central pattern generator modifies or disrupts rhythmic motor output.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2007Article
- Characterization of the Caenorhabditis elegans G protein-coupled serotonin receptors.Invertebrate neuroscience : IN · 2006Article
- Parallel somatic and synaptic processing in the induction of intermediate-term and long-term synaptic facilitation in Aplysia.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Serotonin release evoked by tail nerve stimulation in the CNS of aplysia: characterization and relationship to heterosynaptic plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Levels of serotonin in the hemolymph of Aplysia are modulated by light/dark cycles and sensitization training.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Cloning and characterization of Aplysia neutral endopeptidase, a metallo-endopeptidase involved in the extracellular metabolism of neuropeptides in Aplysia californica.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Multiple serotonergic mechanisms contributing to sensitization in aplysia: evidence of diverse serotonin receptor subtypes.Learning & memory (Cold Spring Harbor, N.Y.)Review
- Quantitation of contacts among sensory, motor, and serotonergic neurons in the pedal ganglion of aplysia.Learning & memory (Cold Spring Harbor, N.Y.)Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serotonin (5-HT) is involved in the control of various behaviors in Aplysia californica, including reproduction, feeding, locomotion, circadian rhythm, synaptic plasticity, and synaptic growth. The large variety of functions of 5-HT is mediated by different receptor subtypes that are coupled to different second-messenger systems. Here, we report the cloning of a cDNA coding for an Aplysia G-protein-coupled 5-HT receptor (5-HTap1). Its deduced amino acid sequence resembles those of the 5-HT1 receptor subfamily. When expressed in stable cell lines, 5-HTap1 exhibits high-affinity binding for the serotonergic radioligand [N-methyl-3H]lysergic acid diethylamide. This binding is competed by several 5-HT agonists and antagonists, and the pharmacological profile of inhibition has some similarities with those of 5-HT1 and 5-HT7 receptors. Application of 5-HT or its agonists 5-carboxamidotryptamine maleate and (+/-)-8-hydroxy-2-(di-n-propyl-amino) tetralin hydrobromide on cells transformed with 5-HTap1 produced a dose-dependent inhibition of forskolin-stimulated cAMP accumulation. 5-HTap1 is thus negatively coupled to adenylate cyclase. The production of antiserum against the 5-HTap1 receptor allowed us to examine its expression in animal tissues. The receptor protein is detected in every tissue examined, although it seems only weakly expressed in some samples. The receptor is also found in every ganglia of the nervous system, both in the sheath and in the neurons. 5-HTap1 mRNA is absent from the sheath, indicating that the protein observed there is probably located on the nerve terminals.
Indexed as
Identifiers
9671650PMC6793050W1881742754What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.