ArticleMolecular and cellular biology1998
Yeast Ty1 retrotransposition is stimulated by a synergistic interaction between mutations in chromatin assembly factor I and histone regulatory proteins.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 55 citations in OpenAlex.
- In vivo continuous evolution of genes and pathways in yeast.Nature communications · 2016Article
- The Ty1 LTR-retrotransposon of budding yeast,Microbiology spectrum · 2015Article
- The impact of the HIRA histone chaperone upon global nucleosome architecture.Cell cycle (Georgetown, Tex.) · 2015Article
- γH2A-binding protein Brc1 affects centromere function in fission yeast.Molecular and cellular biology · 2013Article
- Separation-of-function mutation in HPC2, a member of the HIR complex in S. cerevisiae, results in derepression of the histone genes but does not confer cryptic TATA phenotypes.Biochimica et biophysica acta · 2011Article
- Adaptation to diverse nitrogen-limited environments by deletion or extrachromosomal element formation of the GAP1 locus.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Silencing mediated by the Schizosaccharomyces pombe HIRA complex is dependent upon the Hpc2-like protein, Hip4.PloS one · 2010Article
- The fission yeast HIRA histone chaperone is required for promoter silencing and the suppression of cryptic antisense transcripts.Molecular and cellular biology · 2009Article
- Identical sequences but different expression patterns of Hira gene in gynogenetic and gonochoristic crucian carps.Fish physiology and biochemistry · 2008Article
- Chromatin-associated genes protect the yeast genome from Ty1 insertional mutagenesis.Genetics · 2008Article
- Mutual interdependence of MSI1 (CAC3) and YAK1 in Saccharomyces cerevisiae.Journal of molecular biology · 2007Article
- Regulation of histone deposition proteins Asf1/Hir1 by multiple DNA damage checkpoint kinases in Saccharomyces cerevisiae.Genetics · 2005Article
- The HIR corepressor complex binds to nucleosomes generating a distinct protein/DNA complex resistant to remodeling by SWI/SNF.Genes & development · 2005Article
- Rtt106p is a histone chaperone involved in heterochromatin-mediated silencing.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Reduction of nucleosome assembly during new DNA synthesis impairs both major pathways of double-strand break repair.Nucleic acids research · 2005Article
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- The Schizosaccharomyces pombe HIRA-like protein Hip1 is required for the periodic expression of histone genes and contributes to the function of complex centromeres.Molecular and cellular biology · 2004Article
- Functional genomics reveals relationships between the retrovirus-like Ty1 element and its host Saccharomyces cerevisiae.Genetics · 2003Article
- Chromatin proteins are determinants of centromere function.Current topics in microbiology and immunology · 2003Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
A screen for host mutations which increase the rate of transposition of Ty1 and Ty2 into a chromosomal target was used to identify factors influencing retroelement transposition. The fortuitous presence of a mutation in the CAC3 gene in the strain in which this screen was undertaken enabled us to discover that double mutaions of cac3 and hir3, but neither of the two single mutations, caused a dramatic increase in the rate of retrotransposition. We further showed that this effect was not due to an increase in the overall level of Ty1 mRNA. Two subtle cac3 phenotypes, slight methyl methanesulfonate (MMS) sensitivity and reduction of telomeric silencing, were significantly enhanced in the cac3 hir3 double mutant. In addition, the growth rate of the double mutant was reduced. HIR3 belongs to a class of HIR genes that regulate the transcription of histones, while Cac3p, together with Cac1p and Cac2p, forms chromatin assembly factor I. Other combinations of mutations in cac and hir genes (cac3 hir1, cac3 hir2, and cac2 hir3) also increase Ty transposition and MMS sensitivity and reduce the growth rate. A model explaining the synergistic interaction between cac and hir mutations in terms of alterations in chromatin structure is proposed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.