ArticleMolecular and cellular biology1998
Snf1 kinase connects nutritional pathways controlling meiosis in Saccharomyces cerevisiae.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 86 citations in OpenAlex.
- Whether Gametophytes are Reduced or Unreduced in Angiosperms Might Be Determined Metabolically.Genes · 2020Article
- Sporulation inJournal of fungi (Basel, Switzerland) · 2020Review
- Regulated repression governs the cell fate promoter controlling yeast meiosis.Nature communications · 2020Article
- How Boundaries Form: Linked Nonautonomous Feedback Loops Regulate Pattern Formation in Yeast Colonies.Genetics · 2019Article
- Circadian Regulation of Alternative Splicing of Drought-Associated CIPK Genes inInternational journal of molecular sciences · 2019Article
- Compensatory Internalization of Pma1 in V-ATPase Mutants inGenetics · 2018Article
- Genomic and transcriptomic analyses of the tangerine pathotype of Alternaria alternata in response to oxidative stress.Scientific reports · 2016Article
- Nutrient Control of Yeast Gametogenesis Is Mediated by TORC1, PKA and Energy Availability.PLoS genetics · 2016Article
- Cell Differentiation and Spatial Organization in Yeast Colonies: Role of Cell-Wall Integrity Pathway.Genetics · 2015Article
- Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae.FEMS microbiology reviews · 2014Review
- Functional characterization of sucrose non-fermenting 1 protein kinase complex genes in the Ascomycete Fusarium graminearum.Current genetics · 2014Article
- Orquestic regulation of neurotransmitters on reward-seeking behavior.International archives of medicine · 2014Review
- Dynamic modeling of yeast meiotic initiation.BMC systems biology · 2013Article
- The Sum1/Ndt80 transcriptional switch and commitment to meiosis in Saccharomyces cerevisiae.Microbiology and molecular biology reviews : MMBR · 2012Review
- Snf1-like protein kinase Ssp2 regulates glucose derepression in Schizosaccharomyces pombe.Eukaryotic cell · 2012Article
- Pleiotropic signaling pathways orchestrate yeast development.Current opinion in microbiology · 2011Review
- Sporulation in the budding yeast Saccharomyces cerevisiae.Genetics · 2011Review
- AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function.Genes & development · 2011Review
- TaSnRK2.4, an SNF1-type serine/threonine protein kinase of wheat (Triticum aestivum L.), confers enhanced multistress tolerance in Arabidopsis.Journal of experimental botany · 2010Article
- GzSNF1 is required for normal sexual and asexual development in the ascomycete Gibberella zeae.Eukaryotic cell · 2009Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glucose inhibits meiosis in Saccharomyces cerevisiae at three different steps (IME1 transcription, IME2 transcription, and entry into late stages of meiosis). Because many of the regulatory effects of glucose in yeast are mediated through the inhibition of Snf1 kinase, a component of the glucose repression pathway, we determined the role of SNF1 in regulating meiosis. Deleting SNF1 repressed meiosis at the same three steps that were inhibited by glucose, suggesting that glucose blocks meiosis by inhibiting Snf1. For example, the snf1Delta mutant completely failed to induce IME1 transcripts in sporulation medium. Furthermore, even when this block was bypassed by expression of IME1 from a multicopy plasmid, IME2 transcription and meiotic initiation occurred at only 10 to 20% of the levels seen in wild-type cells. The addition of glucose did not further inhibit IME2 transcription, suggesting that Snf1 is the primary mediator of glucose controls on IME2 expression. Finally, in snf1Delta cells in which both blocks on meiotic initiation were bypassed, early stages of meiosis (DNA replication and commitment to recombination) occurred, but later stages (chromosome segregation and spore formation) did not, suggesting that Snf1 controls later stages of meiosis independently from the two controls on meiotic initiation. Because Snf1 is known to activate the expression of genes required for acetate metabolism, it may also serve to connect glucose and acetate controls on meiotic differentiation.
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