ArticleMolecular and cellular biology1998
TFII-I regulates Vbeta promoter activity through an initiator element.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 59 citations in OpenAlex.
- Risk Allele rs117026326-Mediated Alternative Splicing of GTF2I Promotes B Cell Proliferation in Primary Sjögren's Syndrome.Journal of immunology research · 2025Article
- TFII-I-mediated polymerase pausing antagonizes GLI2 induction by TGFβ.Nucleic acids research · 2020Article
- A Novel Interaction between TFII-I and Mdm2 with a Negative Effect on TFII-I Transcriptional Activity.PloS one · 2015Article
- A stimulation-dependent alternate core promoter links lymphotoxin α expression with TGF-β1 and fibroblast growth factor-7 signaling in primary human T cells.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Characterization and expression of bone morphogenetic protein 4 gene in postnatal pigs.Molecular biology reports · 2010Article
- Williams-Beuren syndrome-associated transcription factor TFII-I regulates osteogenic marker genes.The Journal of biological chemistry · 2009Article
- Characterization of a novel interaction between transcription factor TFII-I and the inducible tyrosine kinase in T cells.European journal of immunology · 2009Article
- The complex of TFII-I, PARP1, and SFPQ proteins regulates the DYX1C1 gene implicated in neuronal migration and dyslexia.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2008Article
- Antagonistic regulation of beta-globin gene expression by helix-loop-helix proteins USF and TFII-I.Molecular and cellular biology · 2006Article
- Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I.Molecular and cellular biology · 2006Article
- Inhibition of TFII-I-dependent cell cycle regulation by p53.Molecular and cellular biology · 2005Article
- Positive and negative regulation of the transforming growth factor beta/activin target gene goosecoid by the TFII-I family of transcription factors.Molecular and cellular biology · 2005Article
- TFII-I regulates induction of chromosomally integrated human immunodeficiency virus type 1 long terminal repeat in cooperation with USF.Journal of virology · 2005Article
- Bruton's tyrosine kinase regulates immunoglobulin promoter activation in association with the transcription factor Bright.Molecular and cellular biology · 2005Article
- Comparison of TFII-I gene family members deleted in Williams-Beuren syndrome.Protein science : a publication of the Protein Society · 2004Article
- Core promoter structure in the oomycete Phytophthora infestans.Eukaryotic cell · 2004Article
- Upstream stimulatory factors are mediators of Ca2+-responsive transcription in neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Normal transcription of the C1 inhibitor gene is dependent upon a polypurine-polypyrimidine region within the promoter.Inflammation · 2002Article
- Repression of TFII-I-dependent transcription by nuclear exclusion.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Identification of TFII-I as the endoplasmic reticulum stress response element binding factor ERSF: its autoregulation by stress and interaction with ATF6.Molecular and cellular biology · 2001Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In our effort to understand the transcriptional regulation of naturally occurring TATA-less but initiator (Inr)-containing genes, we have employed the murine T-cell receptor Vbeta 5.2 promoter as a model. Here we show by transient-transfection assays that the Inr binding transcription factor TFII-I is required for efficient expression of the Vbeta promoter in vivo. Mutations in the Inr element that reduced binding of TFII-I also abolished the Vbeta promoter activity by ectopic TFII-I. We further biochemically identified a protease-resistant N-terminal DNA binding fragment of TFII-I, p70. When ectopically expressed, recombinant p70 bound to the Vbeta Inr element with a specificity similar to that of wild-type TFII-I. More importantly, p70, which lacks independent activation functions, behaved as a dominant negative mutant that inhibited Inr-specific function of wild-type TFII-I. However, the activation functions of p70 were restored when fused to the heterologous activation domain of the yeast activator protein GAL4. Taken together, these data suggest that TFII-I functions in vivo require an intact Inr element and that the Inr-specific transcriptional functions of TFII-I are solely dictated by its N-terminal DNA binding domain and do not require its own C-terminal activation domain.
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