ArticleMolecular and cellular biology1998
An alternative promoter in the mouse major histocompatibility complex class II I-Abeta gene: implications for the origin of CpG islands.
Article in Molecular and cellular biology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 65 citations in OpenAlex.
- Classification and characterization of alternative promoters in 26 lung adenocarcinoma cell lines.Japanese journal of clinical oncology · 2023Article
- Chromatin Regulation and the Histone Code in HIV Latency .The Yale journal of biology and medicine · 2017Review
- Article
- Evaluating the sensitivity of hybridization-based epigenotyping using a methyl binding domain protein.The Analyst · 2014Article
- Redox-based epigenetic status in drug addiction: a potential contributor to gene priming and a mechanistic rationale for metabolic intervention.Frontiers in neuroscience · 2014Review
- Single-stranded noncoding RNAs mediate local epigenetic alterations at gene promoters in rat cell lines.The Journal of biological chemistry · 2011Article
- CpG islands and the regulation of transcription.Genes & development · 2011Review
- Orphan CpG islands identify numerous conserved promoters in the mammalian genome.PLoS genetics · 2010Article
- Transcription initiation activity sets replication origin efficiency in mammalian cells.PLoS genetics · 2009Article
- A novel CpG island set identifies tissue-specific methylation at developmental gene loci.PLoS biology · 2008Article
- Promoter-dependent mechanism leading to selective hypomethylation within the 5' region of gene MAGE-A1 in tumor cells.Molecular and cellular biology · 2004Article
- A comprehensive analysis of allelic methylation status of CpG islands on human chromosome 21q.Genome research · 2004Article
- Methylation of CpG dinucleotides in the open reading frame of a testicular germ cell-specific intronless gene, Tact1/Actl7b, represses its expression in somatic cells.Nucleic acids research · 2003Article
- Review
- DNA methylation and breast carcinogenesis.Oncogene · 2002Review
- Determinants of CpG islands: expression in early embryo and isochore structure.Genome research · 2001Article
- Cloning of a mammalian transcriptional activator that binds unmethylated CpG motifs and shares a CXXC domain with DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1.Molecular and cellular biology · 2000Article
- Roles of cell division and gene transcription in the methylation of CpG islands.Molecular and cellular biology · 1999Article
- Confluence-induced alterations in CpG island methylation in cultured normal human fibroblasts.Nucleic acids research · 1999Article
- An origin of bidirectional DNA replication is located within a CpG island at the 3" end of the chicken lysozyme gene.Nucleic acids research · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Nonmethylated CpG islands are generally located at the 5' ends of genes, but a CpG island in the mouse major histocompatibility complex class II I-Abeta gene is remote from the promoter and covers exon 2. We have found that this CpG island includes a novel intronic promoter that is active in embryonic and germ cells. The resulting transcript potentially encodes a severely truncated protein which would lack the signal peptide and external beta1 domains. The functional significance of the internal CpG island may be to facilitate gene conversion, thereby sustaining the high level of polymorphism seen at exon 2. Deletions of the I-Abeta CpG island promoter reduce transcription and frequently lead to methylation of the CpG island in a transgenic mouse assay. These and other results support the idea that all CpG islands arise at promoters that are active in early embryonic cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.