ArticleRNA (New York, N.Y.)1998
Nucleolar localization elements in U8 snoRNA differ from sequences required for rRNA processing.
Article in RNA (New York, N.Y.), 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 35 citations in OpenAlex.
- The small nucleolar RNA SnoR28 regulates plant growth and development by directing rRNA maturation.The Plant cell · 2022Article
- Analysis of U8 snoRNA Variants in Zebrafish Reveals How Bi-allelic Variants Cause Leukoencephalopathy with Calcifications and Cysts.American journal of human genetics · 2020Article
- Hydrolytic activity of human Nudt16 enzyme on dinucleotide cap analogs and short capped oligonucleotides.RNA (New York, N.Y.) · 2018Article
- RNA modification in Cajal bodies.RNA biology · 2017Review
- Assembly and trafficking of box C/D and H/ACA snoRNPs.RNA biology · 2017Review
- The human box C/D snoRNAs U3 and U8 are required for pre-rRNA processing and tumorigenesis.Oncotarget · 2016Article
- Chemotherapy targeting by DNA capture in viral protein particles.Nanomedicine (London, England) · 2012Article
- Identification of genes that function in the biogenesis and localization of small nucleolar RNAs in Saccharomyces cerevisiae.Molecular and cellular biology · 2008Article
- Uncapped mRNA introduced into tobacco protoplasts can be imported into the nucleus and is trapped by leptomycin B.Plant cell reports · 2004Article
- Degradation of normal mRNA in the nucleus of Saccharomyces cerevisiae.Molecular and cellular biology · 2003Article
- Conserved stem II of the box C/D motif is essential for nucleolar localization and is required, along with the 15.5K protein, for the hierarchical assembly of the box C/D snoRNP.Molecular and cellular biology · 2002Article
- All small nuclear RNAs (snRNAs) of the [U4/U6.U5] Tri-snRNP localize to nucleoli; Identification of the nucleolar localization element of U6 snRNA.Molecular biology of the cell · 2002Article
- Xenopus LSm proteins bind U8 snoRNA via an internal evolutionarily conserved octamer sequence.Molecular and cellular biology · 2002Article
- Small nucleolar RNAs: versatile trans-acting molecules of ancient evolutionary origin.Gene expression · 2002Review
- Fluorescent RNA cytochemistry: tracking gene transcripts in living cells.Nucleic acids research · 2001Review
- The box C/D motif directs snoRNA 5'-cap hypermethylation.Nucleic acids research · 2000Article
- Transient nucleolar localization Of U6 small nuclear RNA in Xenopus Laevis oocytes.Molecular biology of the cell · 2000Article
- Multiple conserved segments of E1 small nucleolar RNA are involved in the formation of a ribonucleoprotein particle in frog oocytes.The Biochemical journal · 2000Article
- Nuclear retention elements of U3 small nucleolar RNA.Molecular and cellular biology · 1999Article
- Assembly of the nuclear transcription and processing machinery: Cajal bodies (coiled bodies) and transcriptosomes.Molecular biology of the cell · 1999Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
U8 small nucleolar RNA (snoRNA) is essential for metazoan ribosomal RNA (rRNA) processing in nucleoli. The sequences and structural features in Xenopus U8 snoRNA that are required for its nucleolar localization were analyzed. Fluorescein-labeled U8 snoRNA was injected into Xenopus oocyte nuclei, and fluorescence microscopy of nucleolar preparations revealed that wild-type Xenopus U8 snoRNA localized to nucleoli, regardless of the presence or nature of the 5' cap on the injected U8 snoRNA. Nucleolar localization was observed when loops or stems in the 5' portion of U8 that are critical for U8 snoRNA function in rRNA processing were mutated. Therefore, sites of interaction in U8 snoRNA that potentially tether it to pre-rRNA are not essential for nucleolar localization of U8. Boxes C and D are known to be nucleolar localization elements (NoLEs) for U8 snoRNA and other snoRNAs of the Box C/D family. However, the spatial relationship of Box C to Box D was not crucial for U8 nucleolar localization, as demonstrated here by deletion of sequences in the two stems that separate them. These U8 mutants can localize to nucleoli and function in rRNA processing as well. The single-stranded Cup region in U8, adjacent to evolutionarily conserved Box C, functions as a NoLE in addition to Boxes C and D. Cup is unique to U8 snoRNA and may help bind putative protein(s) needed for nucleolar localization. Alternatively, Cup may help to retain U8 snoRNA within the nucleolus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.