ArticleThe Journal of experimental medicine1998
An opposite pattern of selection of a single T cell antigen receptor in the thymus and among intraepithelial lymphocytes.
Article in The Journal of experimental medicine, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 64 citations in OpenAlex.
- Destined for the intestine: thymic selection of TCRαβ CD8αα intestinal intraepithelial lymphocytes.Clinical and experimental immunology · 2023Review
- Increased TCR signal strength in DN thymocytes promotes development of gut TCRαβScientific reports · 2017Article
- Optimal T-cell receptor affinity for inducing autoimmunity.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Location, location, location: tissue-specific regulation of immune responses.Journal of leukocyte biology · 2013Review
- Clonal deletion and the fate of autoreactive thymocytes that survive negative selection.Nature immunology · 2012Article
- Selection of self-reactive T cells in the thymus.Annual review of immunology · 2012Review
- Developing intestinal fortitude.Nature immunology · 2011Article
- Intestinal T cells: facing the mucosal immune dilemma with synergy and diversity.Seminars in immunology · 2009Review
- Endogenous galectin-1 enforces class I-restricted TCR functional fate decisions in thymocytes.Blood · 2008Article
- The same genomic region conditions clonal deletion and clonal deviation to the CD8alphaalpha and regulatory T cell lineages in NOD versus C57BL/6 mice.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Mucosal T lymphocytes--peacekeepers and warriors.Springer seminars in immunopathology · 2005Review
- Significance of unconventional peripheral CD4+CD8dim T cell subsets.Journal of clinical immunology · 2005Article
- The timing of TCR alpha expression critically influences T cell development and selection.The Journal of experimental medicine · 2005Article
- Inducible lymphoid tissues in the adult gut: recapitulation of a fetal developmental pathway?Nature reviews. Immunology · 2005Review
- A unique subset of self-specific intraintestinal T cells maintains gut integrity.The Journal of experimental medicine · 2002Article
- Positive selection of an MHC class-I restricted TCR in the absence of classical MHC class I molecules.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Autospecific gammadelta thymocytes that escape negative selection find sanctuary in the intestine.The Journal of clinical investigation · 1999Article
- High- and low-affinity single-peptide/MHC ligands have distinct effects on the development of mucosal CD8alphaalpha and CD8alphabeta T lymphocytes.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The differentiation of intestinal intraepithelial lymphocytes (IEL) remains controversial, which may be due in part to the phenotypic complexity of these T cells. We have investigated here the development of IEL in mice on the recombination activating gene (RAG)-2(-/-) background which express a T cell antigen receptor (TCR) transgene specific for an H-Y peptide presented by Db (H-Y/Db x RAG-2(-) mice). In contrast to the thymus, the small intestine in female H-Y/Db x RAG-2(-) mice is severely deficient in the number of IEL; TCR transgene+ CD8alphaalpha and CD8alphabeta are virtually absent. This is similar to the number and phenotype of IEL in transgenic mice that do not express the Db class I molecule, and which therefore fail positive selection. Paradoxically, in male mice, the small intestine contains large numbers of TCR+ IEL that express high levels of CD8alphaalpha homodimers. The IEL isolated from male mice are functional, as they respond upon TCR cross-linking, although they are not autoreactive to stimulator cells from male mice. We hypothesize that the H-Y/Db TCR fails to undergo selection in IEL of female mice due to the reduced avidity of the TCR for major histocompatibility complex peptide in conjunction with the CD8alphaalpha homodimers expressed by many cells in this lineage. By contrast, this reduced TCR/CD8alphaalpha avidity may permit positive rather than negative selection of this TCR in male mice. Therefore, the data presented provide conclusive evidence that a TCR which is positively selected in the thymus will not necessarily be selected in IEL, and furthermore, that the expression of a distinct CD8 isoform by IEL may be a critical determinant of the differential pattern of selection of these T cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.