ArticleThe EMBO journal1998
DNA binding by the KP repressor protein inhibits P-element transposase activity in vitro.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 70 citations in OpenAlex.
- Article
- Rapid emergence of non-autonomous elements may stop P-element invasions in the absence of a piRNA-based host defence.PLoS genetics · 2025Article
- Experimentally evolvingGenome research · 2024Article
- P-element invasion fuels molecular adaptation in laboratory populations of Drosophila melanogaster.Evolution; international journal of organic evolution · 2023Article
- Mechanism and regulation of P element transposition.Open biology · 2020Review
- Paternally Inherited P-Element Copy Number Affects the Magnitude of Hybrid Dysgenesis in Drosophila simulans and D. melanogaster.Genome biology and evolution · 2020Article
- Tracking a recent horizontal transfer event: The P-element reaches Brazilian populations of Drosophila simulans.Genetics and molecular biology · 2020Article
- Structure of a P element transposase-DNA complex reveals unusual DNA structures and GTP-DNA contacts.Nature structural & molecular biology · 2019Article
- Molecular dissection of a natural transposable element invasion.Genome research · 2018Article
- Association of zygotic piRNAs derived from paternalMobile DNA · 2018Article
- Reexamining the P-Element Invasion of Drosophila melanogaster Through the Lens of piRNA Silencing.Genetics · 2016Review
- Cytotype Regulation Facilitates Repression of Hybrid Dysgenesis by Naturally Occurring KP Elements in Drosophila melanogaster.G3 (Bethesda, Md.) · 2016Article
- P Transposable Elements in Drosophila and other Eukaryotic Organisms.Microbiology spectrum · 2015Review
- Transposon regulation in Drosophila: piRNA-producing P elements facilitate repression of hybrid dysgenesis by a P element that encodes a repressor polypeptide.Molecular genetics and genomics : MGG · 2015Article
- A green fluorescent protein solubility screen in E. coli reveals domain boundaries of the GTP-binding domain in the P element transposase.Protein science : a publication of the Protein Society · 2010Article
- THAP proteins target specific DNA sites through bipartite recognition of adjacent major and minor grooves.Nature structural & molecular biology · 2010Article
- The nsdC gene encoding a putative C2H2-type transcription factor is a key activator of sexual development in Aspergillus nidulans.Genetics · 2009Article
- Cytotype regulation of P transposable elements in Drosophila melanogaster: repressor polypeptides or piRNAs?Genetics · 2008Article
- The Foldback-like element Galileo belongs to the P superfamily of DNA transposons and is widespread within the Drosophila genus.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- gon-14 functions with class B and class C synthetic multivulva genes to control larval growth in Caenorhabditis elegans.Genetics · 2006Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
P elements are a family of mobile DNA elements found in Drosophila. P-element transposition is tightly regulated, and P-element-encoded repressor proteins are responsible for inhibiting transposition in vivo. To investigate the molecular mechanisms by which one of these repressors, the KP protein, inhibits transposition, a variety of mutant KP proteins were prepared and tested for their biochemical activities. The repressor activities of the wild-type and mutant KP proteins were tested in vitro using several different assays for P-element transposase activity. These studies indicate that the site-specific DNA-binding activity of the KP protein is essential for repressing transposase activity. The DNA-binding domain of the KP repressor protein is also shared with the transposase protein and resides in the N-terminal 88 amino acids. Within this region, there is a C2HC putative metal-binding motif that is required for site-specific DNA binding. In vitro the KP protein inhibits transposition by competing with the transposase enzyme for DNA-binding sites near the P-element termini.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.