ArticleThe EMBO journal1998
Invasion of T-lymphoma cells: cooperation between Rho family GTPases and lysophospholipid receptor signaling.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
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Who cites it
62 citing papers in PubMed, 221 citations in OpenAlex.
- Hyaluronan Receptors as Mediators and Modulators of the Tumor Microenvironment.Advanced healthcare materials · 2023Review
- Targeting lysophosphatidic acid receptor with Ki16425 impedes T cell lymphoma progression through apoptosis induction, glycolysis inhibition, and activation of antitumor immune response.Apoptosis : an international journal on programmed cell death · 2022Article
- The Role of Lysophosphatidic Acid in Adult Stem Cells.International journal of stem cells · 2020Review
- Sphingosine 1-Phosphate (S1P)/ S1P Receptor Signaling and Mechanotransduction: Implications for Intrinsic Tissue Repair/Regeneration.International journal of molecular sciences · 2019Review
- Discovery and synthetic optimization of a novel scaffold for hydrophobic tunnel-targeted autotaxin inhibition.Bioorganic & medicinal chemistry · 2016Article
- Biological effects of RNAi targeted inhibiting Tiam1 gene expression on cholangiocarcinoma cells.International journal of clinical and experimental pathology · 2015Article
- The autotaxin-LPA axis emerges as a novel regulator of lymphocyte homing and inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2014Review
- Article
- ROCK inhibition activates MCF-7 cells.PloS one · 2014Article
- Article
- Anti-S100A4 antibody suppresses metastasis formation by blocking stroma cell invasion.Neoplasia (New York, N.Y.) · 2012Article
- Autotaxin through lysophosphatidic acid stimulates polarization, motility, and transendothelial migration of naive T cells.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes.The Journal of experimental medicine · 2012Article
- Membrane dynamics correlate with formation of signaling clusters during cell spreading.Biophysical journal · 2012Article
- Ethanol extracts of fruiting bodies of Antrodia cinnamomea suppress CL1-5 human lung adenocarcinoma cells migration by inhibiting matrix metalloproteinase-2/9 through ERK, JNK, p38, and PI3K/Akt signaling pathways.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Effects of lysophospholipids on tumor microenvironment.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2011Article
- Sphingolipid signaling and hematopoietic malignancies: to the rheostat and beyond.Anti-cancer agents in medicinal chemistry · 2011Review
- Targeting sphingosine-1-phosphate in hematologic malignancies.Anti-cancer agents in medicinal chemistry · 2011Review
- LPA is a chemorepellent for B16 melanoma cells: action through the cAMP-elevating LPA5 receptor.PloS one · 2011Article
- PTHrP promotes colon cancer cell migration and invasion in an integrin α6β4-dependent manner through activation of Rac1.Cancer letters · 2010Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rho-like GTPases orchestrate distinct cytoskeletal changes in response to receptor stimulation. Invasion of T-lymphoma cells into a fibroblast monolayer is induced by Tiam1, an activator of the Rho-like GTPase Rac, and by constitutively active V12Rac1. Here we show that activated V12Cdc42 can also induce invasion of T-lymphoma cells. Activated RhoA potentiates invasion, but fails by itself to mimic Rac and Cdc42. However, invasion is inhibited by the Rho-inactivating C3 transferase. Thus, RhoA is required but not sufficient for invasion. Invasion of T-lymphoma cells is critically dependent on the presence of serum. Serum can be replaced by the serum-borne lipids lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) (10(-7)-10(-6) M), which act on distinct G protein-linked receptors to activate RhoA and phospholipase C (PLC)-Ca2+ signaling. LPA- and S1P-induced invasion is preceded by Rho-dependent F-actin redistribution and pseudopodia formation. However, expression of both V14RhoA and V12Rac1 does not bypass the LPA/S1P requirement for invasion, indicating involvement of an additional signaling pathway independent of RhoA. The PLC inhibitor U-73122, but not the inactive analog U-73343, abolishes invasion. Our results indicate that T-lymphoma invasion is driven by Tiam1/Rac or Cdc42 activation, and is dependent on LPA/S1P receptor-mediated RhoA and PLC signaling pathways which lead to pseudopod formation and enhanced infiltration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.