ArticleThe EMBO journal1998
Developmentally and spatially regulated activation of a Dictyostelium STAT protein by a serpentine receptor.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 110 citations in OpenAlex.
- LrrkA, a kinase with leucine-rich repeats, links folate sensing with Kil2 activity and intracellular killing.Cellular microbiology · 2020Article
- Eat Prey, Live:Frontiers in immunology · 2017Review
- Copine A is expressed in prestalk cells and regulates slug phototaxis and thermotaxis in developing Dictyostelium.Development, growth & differentiation · 2011Article
- Tyrosine phosphorylation-mediated signaling pathways in dictyostelium.Journal of signal transduction · 2011Article
- The role of Gbetagamma subunits in the organization, assembly, and function of GPCR signaling complexes.Annual review of pharmacology and toxicology · 2009Review
- Evidence that DIF-1 and hyper-osmotic stress activate a Dictyostelium STAT by inhibiting a specific protein tyrosine phosphatase.Development (Cambridge, England) · 2008Article
- GBF-dependent family genes morphologically suppress the partially active Dictyostelium STATa strain.Development genes and evolution · 2008Article
- Evidence that noncoding RNA dutA is a multicopy suppressor of Dictyostelium discoideum STAT protein Dd-STATa.Eukaryotic cell · 2007Article
- Proteomic and microarray analyses of the Dictyostelium Zak1-GSK-3 signaling pathway reveal a role in early development.Eukaryotic cell · 2007Article
- Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR.The EMBO journal · 2007Article
- Transcriptional regulation of Dictyostelium pattern formation.EMBO reports · 2006Review
- Activation of soluble guanylyl cyclase at the leading edge during Dictyostelium chemotaxis.Molecular biology of the cell · 2005Article
- Extracellular matrix family proteins that are potential targets of Dd-STATa in Dictyostelium discoideum.Journal of plant research · 2004Article
- cAMP signaling in Dictyostelium. Complexity of cAMP synthesis, degradation and detection.Journal of muscle research and cell motility · 2002Review
- Ggamma in dictyostelium: its role in localization of gbetagamma to the membrane is required for chemotaxis in shallow gradients.Molecular biology of the cell · 2001Article
- The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Glycogen synthase kinase-3 enhances nuclear export of a Dictyostelium STAT protein.The EMBO journal · 2000Article
- Jak-Stat signal transduction pathway through the eyes of cytokine class II receptor complexes.Oncogene · 2000Review
- Stat3 participates in the metabotropic glutamate signaling pathway in Bergmann glial cells.Neurochemical research · 1999Article
- The chemokine monocyte chemoattractant protein-1 induces functional responses through dimerization of its receptor CCR2.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Dd-STAT, the protein that in part controls Dictyostelium stalk cell differentiation, is a structural and functional homolog of metazoan signal transducers and activators of transcription (STATs). Although present during growth and throughout development, Dd-STAT's tyrosine phosphorylation and nuclear localization are developmentally and spatially regulated. Prior to late aggregation, Dd-STAT is not tyrosine phosphorylated and is not selectively localized in the nucleus. During mound formation, the time at which cell-type specific gene expression initiates, Dd-STAT becomes tyrosine phosphorylated and translocates into the nuclei of all cells. The tyrosine phosphorylation and nuclear localization of Dd-STAT are induced very rapidly by extracellular cAMP through the serpentine cAMP receptor cAR1, with Dd-STAT tyrosine phosphorylation being detectable within 10 s of stimulation. This activation is independent of the only known Gbeta subunit, suggesting that it may be G-protein independent. Nuclear enrichment of Dd-STAT is selectively maintained within the sub-population of prestalk cells that form the tip, the organizing center of the slug, but is lost in most of the other cells of the slug. This spatial patterning of Dd-STAT nuclear localization is consistent with its known role as a negative regulator of stalk-cell differentiation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.