ArticleThe EMBO journal1998
Novel developmentally regulated phosphoinositide binding proteins from soybean whose expression bypasses the requirement for an essential phosphatidylinositol transfer protein in yeast.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 73 citations in OpenAlex.
- A brief history of phosphatidylinositol transfer proteins: from the backwaters of cell biology to prime time in lipid signaling.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2025Review
- Genome-wide identification of the Sec14 gene family and the response to salt and drought stress in soybean (Glycine max).BMC genomics · 2025Article
- OsSNDP3 Functions for the Polar Tip Growth in Rice Pollen Together with OsSNDP2, a Paralog of OsSNDP3.Rice (New York, N.Y.) · 2022Article
- Chloroplast-localized PITP7 is essential for plant growth and photosynthetic function in Arabidopsis.Physiologia plantarum · 2022Article
- A Sec14-like phosphatidylinositol transfer protein paralog defines a novel class of heme-binding proteins.eLife · 2020Article
- A Sec14 domain protein is required for photoautotrophic growth and chloroplast vesicle formation inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Genome-wide identification, phylogeny, and expression analysis of Sec14-like PITP gene family in sugarcane.Plant cell reports · 2019Article
- Sec14-like phosphatidylinositol transfer proteins and the biological landscape of phosphoinositide signaling in plants.Biochimica et biophysica acta · 2016Review
- Two-ligand priming mechanism for potentiated phosphoinositide synthesis is an evolutionarily conserved feature of Sec14-like phosphatidylinositol and phosphatidylcholine exchange proteins.Molecular biology of the cell · 2016Article
- SnRK2 protein kinases--key regulators of plant response to abiotic stresses.Omics : a journal of integrative biology · 2011Review
- Resurrection of a functional phosphatidylinositol transfer protein from a pseudo-Sec14 scaffold by directed evolution.Molecular biology of the cell · 2011Article
- The Sec14-superfamily and the regulatory interface between phospholipid metabolism and membrane trafficking.Biochimica et biophysica acta · 2007Review
- Phosphatidylinositol transfer proteins and functional specification of lipid signaling pools.Advances in enzyme regulation · 2007Article
- Crystallization and preliminary X-ray diffraction analysis of phospholipid-bound Sfh1p, a member of the Saccharomyces cerevisiae Sec14p-like phosphatidylinositol transfer protein family.Acta crystallographica. Section F, Structural biology and crystallization communications · 2006Article
- Specific and nonspecific membrane-binding determinants cooperate in targeting phosphatidylinositol transfer protein beta-isoform to the mammalian trans-Golgi network.Molecular biology of the cell · 2006Article
- A Sec14p-nodulin domain phosphatidylinositol transfer protein polarizes membrane growth of Arabidopsis thaliana root hairs.The Journal of cell biology · 2005Article
- Patellin1, a novel Sec14-like protein, localizes to the cell plate and binds phosphoinositides.Plant physiology · 2004Article
- Biochemical characterization of the tobacco 42-kD protein kinase activated by osmotic stress.Plant physiology · 2004Article
- Analysis of oxysterol binding protein homologue Kes1p function in regulation of Sec14p-dependent protein transport from the yeast Golgi complex.The Journal of cell biology · 2002Article
- Plasma membrane phosphatidylinositol 4,5-bisphosphate levels decrease with time in culture.Plant physiology · 2001Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Phosphatidylinositol transfer proteins (PITPs) have been shown to play important roles in regulating a number of signal transduction pathways that couple to vesicle trafficking reactions, phosphoinositide-driven receptor-mediated signaling cascades, and development. While yeast and metazoan PITPs have been analyzed in some detail, plant PITPs remain entirely uncharacterized. We report the identification and characterization of two soybean proteins, Ssh1p and Ssh2p, whose structural genes were recovered on the basis of their abilities to rescue the viability of PITP-deficient Saccharomyces cerevisiae strains. We demonstrate that, while both Ssh1p and Ssh2p share approximately 25% primary sequence identity with yeast PITP, these proteins exhibit biochemical properties that diverge from those of the known PITPs. Ssh1p and Ssh2p represent high-affinity phosphoinositide binding proteins that are distinguished from each other both on the basis of their phospholipid binding specificities and by their substantially non-overlapping patterns of expression in the soybean plant. Finally, we show that Ssh1p is phosphorylated in response to various environmental stress conditions, including hyperosmotic stress. We suggest that Ssh1p may function as one component of a stress response pathway that serves to protect the adult plant from osmotic insult.
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Registered trials
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