ArticleThe EMBO journal1998
Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 196 citations in OpenAlex.
- Laminin Receptors in Peripheral Tissues: Functions Revealed by Analysis of Knockout Mice.The American journal of pathology · 2025Review
- Laminin Receptors in the CNS and Vasculature.Stroke · 2025Review
- Cell Junctions in Periodontal Health and Disease: An Insight.European journal of dentistry · 2024Article
- Integrinβ-1 in disorders and cancers: molecular mechanisms and therapeutic targets.Cell communication and signaling : CCS · 2024Review
- Regulation of Kinase Signaling Pathways by α6β4-Integrins and Plectin in Prostate Cancer.Cancers · 2022Review
- Identifying key regulators of the intestinal stem cell niche.Biochemical Society transactions · 2021Review
- Comprehensive understanding of anchorage-independent survival and its implication in cancer metastasis.Cell death & disease · 2021Review
- EGFR-dependent tyrosine phosphorylation of integrin β4 is not required for downstream signaling events in cancer cell lines.Scientific reports · 2021Article
- Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance.Cancer cell · 2019Review
- Roles of Integrin α6β4 Glycosylation in Cancer.Cancers · 2017Review
- SYK interaction with ITGβ4 suppressed by Epstein-Barr virus LMP2A modulates migration and invasion of nasopharyngeal carcinoma cells.Oncogene · 2015Article
- Combination of X-ray crystallography, SAXS and DEER to obtain the structure of the FnIII-3,4 domains of integrin α6β4.Acta crystallographica. Section D, Biological crystallography · 2015Article
- Orphan nuclear receptor TR3/Nur77 improves wound healing by upregulating the expression of integrin β4.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Analysis on the relevance of asthma susceptibility with the alteration of integrin β 4 expression.PloS one · 2014Article
- Critical role of S1PR1 and integrin β4 in HGF/c-Met-mediated increases in vascular integrity.The Journal of biological chemistry · 2013Article
- Cross-talk between integrin α6β4 and insulin-like growth factor-1 receptor (IGF1R) through direct α6β4 binding to IGF1 and subsequent α6β4-IGF1-IGF1R ternary complex formation in anchorage-independent conditions.The Journal of biological chemistry · 2012Article
- Epithelial integrins with special reference to oral epithelia.Journal of dental research · 2011Review
- Extracellular matrix functions during neuronal migration and lamination in the mammalian central nervous system.Developmental neurobiology · 2011Review
- Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis.Nature reviews. Molecular cell biology · 2011Review
- Genetic analyses of integrin signaling.Cold Spring Harbor perspectives in biology · 2011Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
The cytoplasmic domain of the integrin beta4 subunit mediates both association with the hemidesmosomal cytoskeleton and recruitment of the signaling adaptor protein Shc. To examine the significance of these interactions during development, we have generated mice carrying a targeted deletion of the beta4 cytoplasmic domain. Analysis of homozygous mutant mice indicates that the tail-less alpha6beta4 binds efficiently to laminin 5, but is unable to integrate with the cytoskeleton. Accordingly, these mice display extensive epidermal detachment at birth and die immmediately thereafter from a syndrome resembling the human disease junctional epidermolysis bullosa with pyloric atresia (PA-JEB). In addition, we find a significant proliferative defect. Specifically, the number of precursor cells in the intestinal epithelium, which remains adherent to the basement membrane, and in intact areas of the skin is reduced, and post-mitotic enterocytes display increased levels of the cyclin-dependent kinase inhibitor p27(Kip). These findings indicate that the interactions mediated by the beta4 tail are crucial for stable adhesion of stratified epithelia to the basement membrane and for proper cell-cycle control in the proliferative compartments of both stratified and simple epithelia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.