ArticleThe EMBO journal1998
Brain spectrin binding to the NMDA receptor is regulated by phosphorylation, calcium and calmodulin.
Article in The EMBO journal, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 190 citations in OpenAlex.
- Biological properties of α-actinin-2 and its role and mechanisms in disease development.Frontiers in physiology · 2026Review
- Article
- Spectrins: molecular organizers and targets of neurological disorders.Nature reviews. Neuroscience · 2023Review
- Functional interactions of ion channels with the actin cytoskeleton: does coupling to dynamic actin regulate NMDA receptors?The Journal of physiology · 2021Review
- Role of actin cytoskeleton in the organization and function of ionotropic glutamate receptors.Current research in structural biology · 2021Review
- A Fresh Look at the Structure, Regulation, and Functions of Fodrin.Molecular and cellular biology · 2020Review
- Cargo hold and delivery: Ankyrins, spectrins, and their functional patterning of neurons.Cytoskeleton (Hoboken, N.J.) · 2020Review
- Altered Proteins in the Hippocampus of Patients with Mesial Temporal Lobe Epilepsy.Pharmaceuticals (Basel, Switzerland) · 2018Article
- Postsynaptic Proteome of Non-Demented Individuals with Alzheimer's Disease Neuropathology.Journal of Alzheimer's disease : JAD · 2018Article
- Lack of the Actin Capping Protein, Eps8, Affects NMDA-Type Glutamate Receptor Function and Composition.Frontiers in molecular neuroscience · 2018Article
- Mechanical stress activates NMDA receptors in the absence of agonists.Scientific reports · 2017Article
- Identification and characterization of a small-molecule inhibitor of death-associated protein kinase 1.Chembiochem : a European journal of chemical biology · 2015Article
- Recent progress in understanding subtype specific regulation of NMDA receptors by G Protein Coupled Receptors (GPCRs).International journal of molecular sciences · 2014Review
- A role for kalirin in the response of rat medium spiny neurons to cocaine.Molecular pharmacology · 2012Article
- N-methyl-D-aspartate receptor mechanosensitivity is governed by C terminus of NR2B subunit.The Journal of biological chemistry · 2012Article
- Negative modulation of NMDA receptor channel function by DREAM/calsenilin/KChIP3 provides neuroprotection?Frontiers in molecular neuroscience · 2012Article
- Kalirin binds the NR2B subunit of the NMDA receptor, altering its synaptic localization and function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Targeting N-methyl-D-aspartate receptors for treatment of neuropathic pain.Expert review of clinical pharmacology · 2011Review
- Differential binding of calmodulin to group I metabotropic glutamate receptors regulates receptor trafficking and signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Beta-III spectrin mutation L253P associated with spinocerebellar ataxia type 5 interferes with binding to Arp1 and protein trafficking from the Golgi.Human molecular genetics · 2010Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The N-methyl-D-aspartate receptor (NMDA-R) and brain spectrin, a protein that links membrane proteins to the actin cytoskeleton, are major components of post-synaptic densities (PSDs). Since the activity of the NMDA-R channel is dependent on the integrity of actin and leads to calpain-mediated spectrin breakdown, we have investigated whether the actin-binding spectrin may interact directly with NMDA-Rs. Spectrin is reported here to interact selectively in vitro with the C-terminal cytoplasmic domains of the NR1a, NR2A and NR2B subunits of the NMDA-R but not with that of the AMPA receptor GluR1. Spectrin binds at NR2B sites distinct from those of alpha-actinin-2 and members of the PSD95/SAP90 family. The spectrin-NR2B interactions are antagonized by Ca2+ and fyn-mediated NR2B phosphorylation, but not by Ca2+/calmodulin (CaM) or by Ca2+/CaM-dependent protein kinase II-mediated NR2B phosphorylation. The spectrin-NR1 interactions are unaffected by Ca2+ but inhibited by CaM and by protein kinase A- and C-mediated phosphorylations of NR1. Finally, in rat synaptosomes, both spectrin and NR2B are loosened from membranes upon addition of physiological concentrations of calcium ions. The highly regulated linkage of the NMDA-R to spectrin may underlie the morphological changes that occur in neuronal dendrites concurrently with synaptic activity and plasticity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.