Evidence map›Paper›PMID 9667657›Full record

ArticleBritish journal of cancer1998

Increased serum p53 antibody levels indicate poor prognosis in patients with colorectal cancer.

U Kressner, B Glimelius, R Bergström, L Påhlman, A Larsson, G Lindmark

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
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  6. Mutant p53 as an Antigen in Cancer Immunotherapy.International journal of molecular sciences · 2020
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  17. Serologic laboratory findings in malignancy.Rheumatic diseases clinics of North America · 2011
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

U KressnerDepartment of Surgery, University Hospital, Uppsala, Sweden.
B Glimelius
R Bergström
L Påhlman
A Larsson
G Lindmark

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serum p53 antibody levels were analysed using an enzyme-linked immunosorbent assay in serum samples obtained before surgery from 184 consecutive patients with primary colorectal cancer. Possible associations with tumour stage and tumour differentiation and the relation to patient survival time after a median follow-up of 6 years were studied. Analysis of serum p53 antibodies in the entire material demonstrated prognostic value in univariate analysis (P = 0.02); a finding that did not remain (P = 0.07) when the Dukes' stage was included in a multivariate analysis model. When the survival analysis was restricted to the potentially cured patients in Dukes' stages A-C, the serum p53 antibody levels retained independent prognostic value (P = 0.03). No clear association with tumour differentiation was found. We conclude that analysis of serum p53 antibodies may be of value for the identification of patients with different prognoses. This may be of relevance for selection of patients for adjuvant treatment.

Indexed as

AdultAgedAged, 80 and overAntibodiesColorectal NeoplasmsFemaleHumansImmunohistochemistryMaleMiddle AgedNeoplasm StagingPrognosisSurvival RateTumor Suppressor Protein p53AntibodiesTumor Suppressor Protein p53

Identifiers

PMID9667657
PMCPMC2150331

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.