ArticleJournal of clinical microbiology1998
Molecular characterization of pneumococcal nasopharynx isolates collected from children during their first 2 years of life.
Article in Journal of clinical microbiology, 1998. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Molecular epidemiology of pneumococcal colonization in response to pneumococcal conjugate vaccination in children with recurrent acute otitis media.Journal of clinical microbiology · 2005Trial
- A comparison of conventional and molecular microbiology in detecting differences in pneumococcal colonization in healthy children and children with upper respiratory illness.European journal of pediatrics · 2010Article
- Impact of capsular switch on invasive pneumococcal disease incidence in a vaccinated population.PloS one · 2008Article
- Characteristics of Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis and Staphylococcus aureus isolated from the nasopharynx of healthy children attending day-care centres in the Czech Republic.Epidemiology and infection · 2006Article
- Novel PCR-restriction fragment length polymorphism method for determining serotypes or serogroups of Streptococcus pneumoniae isolates.Journal of clinical microbiology · 2005Article
- Molecular epidemiology of penicillin-susceptible non-beta-lactam-resistant Streptococcus pneumoniae isolates from Greek children.Journal of clinical microbiology · 2003Article
- Penicillin susceptibility and epidemiological typing of invasive pneumococcal isolates in the Republic of Ireland.Journal of clinical microbiology · 2003Article
- Stability of serotypes during nasopharyngeal carriage of Streptococcus pneumoniae.Journal of clinical microbiology · 2003Article
- Molecular epidemiology of pneumococcal carriage among children with upper respiratory tract infections in Hanoi, Vietnam.Journal of clinical microbiology · 2002Article
- Household transmission of Streptococcus pneumoniae among siblings with acute otitis media.Journal of clinical microbiology · 2002Article
- Pneumococcal carriage in children in The Netherlands: a molecular epidemiological study.Journal of clinical microbiology · 2001Article
- Nomenclature of major antimicrobial-resistant clones of Streptococcus pneumoniae defined by the pneumococcal molecular epidemiology network.Journal of clinical microbiology · 2001Article
- Bacterial infection in chronic obstructive pulmonary disease in 2000: a state-of-the-art review.Clinical microbiology reviews · 2001Review
- Molecular epidemiology of penicillin-susceptible, multidrug-resistant serotype 6B pneumococci isolated from children in Greece.Journal of clinical microbiology · 2001Article
- Molecular epidemiology of penicillin-nonsusceptible Streptococcus pneumoniae among children in Greece.Journal of clinical microbiology · 2000Article
- Genetic relatedness within serotypes of penicillin-susceptible Streptococcus pneumoniae isolates.Journal of clinical microbiology · 2000Article
- Diversity of PspA: mosaic genes and evidence for past recombination in Streptococcus pneumoniae.Infection and immunity · 2000Article
- Immune responses to specific antigens of Streptococcus pneumoniae and Moraxella catarrhalis in the respiratory tract.Infection and immunity · 2000Article
- Nasopharyngeal carriage of penicillin-resistant Streptococcus pneumoniae among children with acute respiratory tract infections in Thailand: a molecular epidemiological survey.Journal of clinical microbiology · 1999Article
- Multidrug-resistant Streptococcus pneumoniae in Poland: identification of emerging clones.Journal of clinical microbiology · 1999Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pneumococcal colonization was studied in 19 children monitored from birth through the age of 2 years. For this purpose, pneumococcal isolates were characterized by capsular typing, restriction fragment end labeling (RFEL), and penicillin-binding protein (PBP) genotyping. Fifty-eight isolates were collected and were found to belong to 10 capsular types, 31 RFEL types, and 7 PBP genotypes. Thirty-nine percent of the isolates had reduced susceptibility to penicillin. All seven highly resistant strains (MICs, > 1 microgram/ml) were identical to the pandemic clone 23F. Children were culture positive between one and eight times at 13 scheduled visits. Although the infants were frequently recolonized with different strains, colonization with one particular strain often persisted for several months. Isolation of a previously detected capsular type was common, and the chromosomal homogeneity tended to be high when it occurred. Horizontal transfer of capsular genes between strains of different RFEL types was demonstrated in one child. The ecological advantage of transfer of capsular genes is unclear unless survival of the organism on a mucosal surface may be linked to immunoprotective pressure against particular capsular types.
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